Effect of non-surgical periodontal treatment on gingival crevicular fluid hypoxia inducible factor-1 alpha, vascular endothelial growth factor and tumor necrosis factor-alpha levels in generalized aggressive periodontitis patients

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dc.contributor.authorAfacan B.
dc.contributor.authorKeleş Yücel Z.P.
dc.contributor.authorPaşali Ç.
dc.contributor.authorAtmaca İlhan H.
dc.contributor.authorKöse T.
dc.contributor.authorEmingil G.
dc.date.accessioned2024-07-22T08:07:11Z
dc.date.available2024-07-22T08:07:11Z
dc.date.issued2020
dc.description.abstractBackground: Hypoxia-inducible angiogenic pathway involving hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α) may regulate several biological processes related to inflammation. The present study aimed to assess the effect of non-surgical periodontal treatment on gingival crevicular fluid (GCF) HIF-1α, VEGF, and TNF-α levels in generalized aggressive periodontitis (G-AgP). Methods: Twenty G-AgP patients and 20 periodontally healthy individuals were included. G-AgP patients received scaling and root planning (SRP), per quadrant at a 1-week-interval, performed with ultrasonic and periodontal hand instruments. GCF samples were collected and clinical periodontal parameters including probing depth, clinical attachment level, gingival index and plaque index were recorded at baseline, 1 and 3 months after treatment. Biomarker levels in GCF were analyzed by ELISA. Results: At baseline all clinical parameters and GCF HIF-1α, VEGF, and TNF-α levels were significantly higher in G-AgP patients compared to healthy control (P < 0.05). All clinical parameters improved over the 3-month-period in G-AgP patients (P < 0.05). GCF HIF-1α levels in G-AgP reduced at 1 and 3 months post-treatment, however, this did not reach to statistical significance (P > 0.05). GCF VEGF and TNF-α levels remained unchanged throughout the study period (P > 0.05). Conclusions: Within the limitations of the present study, although HIF-1α seems to possess a potential diagnostic value for G-AgP, it might not be a proper predictor of clinically favorable treatment outcome. SRP plus different adjunctive therapies could provide better information about the prognostic role of hypoxia-inducible angiogenic pathway in G-AgP. © 2020 The Authors. Journal of Periodontology published by Wiley Periodicals, Inc. on behalf of American Academy of Periodontology
dc.identifier.DOI-ID10.1002/JPER.19-0521
dc.identifier.issn00223492
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13866
dc.language.isoEnglish
dc.publisherWiley-Blackwell
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectAggressive Periodontitis
dc.subjectDental Scaling
dc.subjectGingival Crevicular Fluid
dc.subjectHumans
dc.subjectHypoxia
dc.subjectTumor Necrosis Factor-alpha
dc.subjectVascular Endothelial Growth Factor A
dc.subjecthypoxia inducible factor 1alpha
dc.subjecttumor necrosis factor
dc.subjectvasculotropin
dc.subjecttumor necrosis factor
dc.subjectvasculotropin A
dc.subjectadult
dc.subjectanalytical parameters
dc.subjectArticle
dc.subjectbleeding on probing
dc.subjectclinical article
dc.subjectclinical attachment level
dc.subjectcontrolled study
dc.subjectdental disease assessment
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectfirst molar
dc.subjectgeneralized aggressive periodontitis
dc.subjectgingival index
dc.subjectgingivitis
dc.subjecthuman
dc.subjecthypoxia
dc.subjectmale
dc.subjectmiddle aged
dc.subjectosteolysis
dc.subjectperiodontal disease
dc.subjectperiodontitis
dc.subjectprobing depth
dc.subjectroot length
dc.subjectroot planing
dc.subjectsignal transduction
dc.subjectaggressive periodontitis
dc.subjectchemistry
dc.subjectdental scaling
dc.subjectgingivitis
dc.subjecthypoxia
dc.titleEffect of non-surgical periodontal treatment on gingival crevicular fluid hypoxia inducible factor-1 alpha, vascular endothelial growth factor and tumor necrosis factor-alpha levels in generalized aggressive periodontitis patients
dc.typeArticle

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