Comparison of brucellar and tuberculous spondylodiscitis patients: Results of the multicenter "backbone-1 Study"

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dc.contributor.authorErdem H.
dc.contributor.authorElaldi N.
dc.contributor.authorBatirel A.
dc.contributor.authorAliyu S.
dc.contributor.authorSengoz G.
dc.contributor.authorPehlivanoglu F.
dc.contributor.authorRamosaco E.
dc.contributor.authorGulsun S.
dc.contributor.authorTekin R.
dc.contributor.authorMete B.
dc.contributor.authorBalkan I.I.
dc.contributor.authorSevgi D.Y.
dc.contributor.authorGiannitsioti E.
dc.contributor.authorFragou A.
dc.contributor.authorKaya S.
dc.contributor.authorCetin B.
dc.contributor.authorOktenoglu T.
dc.contributor.authorDogancelik A.
dc.contributor.authorKaraca B.
dc.contributor.authorHorasan E.S.
dc.contributor.authorUlug M.
dc.contributor.authorInan A.
dc.contributor.authorKaya S.
dc.contributor.authorArslanalp E.
dc.contributor.authorAtes-Guler S.
dc.contributor.authorWillke A.
dc.contributor.authorSenol S.
dc.contributor.authorInan D.
dc.contributor.authorGuclu E.
dc.contributor.authorTuncer-Ertem G.
dc.contributor.authorMeric-Koc M.
dc.contributor.authorTasbakan M.
dc.contributor.authorSenbayrak S.
dc.contributor.authorCicek-Senturk G.
dc.contributor.authorSirmatel F.
dc.contributor.authorOcal G.
dc.contributor.authorKocagoz S.
dc.contributor.authorKusoglu H.
dc.contributor.authorGuven T.
dc.contributor.authorBaran A.I.
dc.contributor.authorDede B.
dc.contributor.authorYilmaz-Karadag F.
dc.contributor.authorKose S.
dc.contributor.authorYilmaz H.
dc.contributor.authorAslan G.
dc.contributor.authorAlgallad D.A.
dc.contributor.authorCesur S.
dc.contributor.authorEl-Sokkary R.
dc.contributor.authorBekiroǧlu N.
dc.contributor.authorVahaboglu H.
dc.date.accessioned2024-07-22T08:12:43Z
dc.date.available2024-07-22T08:12:43Z
dc.date.issued2015
dc.description.abstractBackground Context No direct comparison between brucellar spondylodiscitis (BSD) and tuberculous spondylodiscitis (TSD) exists in the literature. Purpose This study aimed to compare directly the clinical features, laboratory and radiological aspects, treatment, and outcome data of patients diagnosed as BSD and TSD. Study Design A retrospective, multinational, and multicenter study was used. Patient Sample A total of 641 (TSD, 314 and BSD, 327) spondylodiscitis patients from 35 different centers in four countries (Turkey, Egypt, Albania, and Greece) were included. Outcome Measures The pre- and peri- or post-treatment spinal deformity and neurologic deficit parameters, and mortality were carried out. Methods Brucellar spondylodiscitis and TSD groups were compared for demographics, clinical, laboratory, radiological, surgical interventions, treatment, and outcome data. The Student t test and Mann-Whitney U test were used for group comparisons. Significance was analyzed as two sided and inferred at 0.05 levels. Results The median baseline laboratory parameters including white blood cell count, C-reactive protein, and erythrocyte sedimentation rate were higher in TSD than BSD (p<.0001). Prevertebral, paravertebral, epidural, and psoas abscess formations along with loss of vertebral corpus height and calcification were significantly more frequent in TSD compared with BSD (p<.01). Surgical interventions and percutaneous sampling or abscess drainage were applied more frequently in TSD (p<.0001). Spinal complications including gibbus deformity, kyphosis, and scoliosis, and the number of spinal neurologic deficits, including loss of sensation, motor weakness, and paralysis were significantly higher in the TSD group (p<.05). Mortality rate was 2.22% (7 patients) in TSD, and it was 0.61% (2 patients) in the BSD group (p=.1). Conclusions The results of this study show that TSD is a more suppurative disease with abscess formation requiring surgical intervention and characterized with spinal complications. We propose that using a constellation of constitutional symptoms (fever, back pain, and weight loss), pulmonary involvement, high inflammatory markers, and radiological findings will help to differentiate between TSD and BSD at an early stage before microbiological results are available. © 2015 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.spinee.2015.09.024
dc.identifier.issn15299430
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16157
dc.language.isoEnglish
dc.publisherElsevier Inc.
dc.subjectAdult
dc.subjectAged
dc.subjectBrucellosis
dc.subjectDiscitis
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectTuberculosis
dc.subjectC reactive protein
dc.subjectceftriaxone
dc.subjectciprofloxacin
dc.subjectcotrimoxazole
dc.subjectdoxycycline
dc.subjectrifampicin
dc.subjectstreptomycin
dc.subjecttuberculostatic agent
dc.subjectabscess
dc.subjectabscess drainage
dc.subjectadult
dc.subjectaged
dc.subjectAlbania
dc.subjectantibiotic therapy
dc.subjectantimicrobial therapy
dc.subjectArticle
dc.subjectbackache
dc.subjectbrucellar spondylodiscitis
dc.subjectbrucellosis
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectEgypt
dc.subjectepidural abscess
dc.subjecterythrocyte sedimentation rate
dc.subjectfatigue
dc.subjectfemale
dc.subjectfever
dc.subjectGreece
dc.subjecthuman
dc.subjectintervertebral disk degeneration
dc.subjectkyphosis
dc.subjectlaboratory test
dc.subjectleukocyte count
dc.subjectloss of appetite
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality rate
dc.subjectmulticenter study (topic)
dc.subjectmuscle weakness
dc.subjectoutcome assessment
dc.subjectparalysis
dc.subjectparavertebral abscess
dc.subjectprevertebral abscess
dc.subjectpriority journal
dc.subjectpsoas abscess
dc.subjectretrospective study
dc.subjectscoliosis
dc.subjectsensory dysfunction
dc.subjectspine disease
dc.subjectspine radiography
dc.subjecttuberculosis
dc.subjecttuberculous spondylodiscitis
dc.subjectTurkey (republic)
dc.subjectweight reduction
dc.subjectbrucellosis
dc.subjectclinical trial
dc.subjectcomplication
dc.subjectDiscitis
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjecttuberculosis
dc.titleComparison of brucellar and tuberculous spondylodiscitis patients: Results of the multicenter "backbone-1 Study"
dc.typeArticle

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