Relationship between C-reactive Protein/Albumin Ratio and Subclinical Inflammation in Patients with Familial Mediterranean Fever; [Korrelation zwischen C-reaktiven Protein/Albumin-Quotienten und subklinischen Entzündungen bei Patienten mit Familiärem Mittelmeerfieber]

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dc.contributor.authorOnder E.N.A.
dc.contributor.authorCam F.S.
dc.contributor.authorErtan P.
dc.date.accessioned2024-07-22T08:05:43Z
dc.date.available2024-07-22T08:05:43Z
dc.date.issued2021
dc.description.abstractBackground Familial Mediterranean Fever (FMF), which is characterised by recurrent episodes of fever with serositis, is associated with ongoing inflammation without clinical findings during attack-free periods, leading to amyloidosis, the most important complication of FMF. The objective of this study was to investigate the C-reactive protein/albumin ratio (CAR) as a marker to identify subclinical inflammation in symptom-free FMF children and compare the CAR with other systemic inflammatory markers such as mean platelet volume (MPV), red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). Material and Methods We included 100 patients and 70 healthy subjects. Hospital records were obtained to collect data on laboratory findings and genetic mutations. Results We found that the CAR levels of our FMF patients were significantly higher than those of the control group. We also evaluated that the CAR values had a higher area-under-thecurve value than the other systemic inflammation parameters including CRP, MPV, RDW, NLR, PLR based on Receiver-Operating Characteristics (ROC) analysis. Conclusion It is important to identify subclinical inflammation in FMF patients with simple, reliable, easily accessible markers to avoid amyloidosis. Although the CAR might be used to assess subclinical inflammation in paediatric FMF patients, the prognostic value of CAR is not superior to CRP. Merging CRP and albumin into a single index thus provides no additional benefit in detecting subclinical inflammation in FMF. © 2021. Thieme. All rights reserved.
dc.identifier.DOI-ID10.1055/a-1403-2309
dc.identifier.issn0341051X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13236
dc.language.isoEnglish
dc.publisherGeorg Thieme Verlag
dc.rightsAll Open Access; Bronze Open Access
dc.subjectalbumin
dc.subjectC reactive protein
dc.subjectArticle
dc.subjectchild
dc.subjectcontrolled study
dc.subjectdiagnostic accuracy
dc.subjectdiagnostic test accuracy study
dc.subjectfamilial Mediterranean fever
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjectinflammation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmean platelet volume
dc.subjectneutrophil lymphocyte ratio
dc.subjectplatelet lymphocyte ratio
dc.subjectreceiver operating characteristic
dc.subjectred blood cell distribution width
dc.subjectretrospective study
dc.subjectschool child
dc.titleRelationship between C-reactive Protein/Albumin Ratio and Subclinical Inflammation in Patients with Familial Mediterranean Fever; [Korrelation zwischen C-reaktiven Protein/Albumin-Quotienten und subklinischen Entzündungen bei Patienten mit Familiärem Mittelmeerfieber]
dc.typeArticle

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