Polymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-1 and apolipoprotein E genes are not associated with carotid intima-media thickness

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dc.contributor.authorAlioglu E.
dc.contributor.authorTurk U.
dc.contributor.authorCam S.
dc.contributor.authorAbbasaliyev A.
dc.contributor.authorTengiz I.
dc.contributor.authorErcan E.
dc.date.accessioned2024-07-22T08:22:04Z
dc.date.available2024-07-22T08:22:04Z
dc.date.issued2009
dc.description.abstractBackground: Single nucleotide polymorphisms in the 5,10-methyl-enetetrahydrofolate reductase (MTHFR), vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), monocyte chemoattractant protein-1 (MCP-1) and apolipoprotein E (ApoE) genes appear to be a genetic risk factor for atherosclerosis. Common carotid intima-media thickness (cIMT) provides information on the severity of atherosclerosis. Objective: To investigate the relationship between cIMT and gene polymorphisms associated with atherosclerosis in Turkish patients with coronary artery disease (CAD). Methods: Sixty-two patients with angiographically diagnosed stable CAD were divided into two groups according to their cIMT values (group 1: n=35, cIMT of 1 mm or greater; group 2: n=27, cIMT of less than 1 mm). MTHFR 677 C/T, VEGF -460 C/T, eNOS 894 G/T, MCP-1 -2518 A/G and ApoE (E2, E3 and E4) gene polymorphisms (where A is adenine, C is cytosine, G is guanine and T is thymine) were analyzed by polymerase chain reaction and restriction fragment length polymorphism. Evaluations of cardiovascular risk factors and coronary atherosclerotic lesions were performed in all patients. Serum homocysteine and high-sensitivity C-reactive protein were measured and compared between the two groups. Results: Serum high-sensitivity C-reactive protein (P=0.04) and homocysteine (P=0.006) levels were higher in group 1 than in group 2. The ratio of multivessel CAD and previous myocardial infarction was significantly higher in group 1 than in group 2 (P=0.014). In the study population, no significant difference in cIMT was observed according to the polymorphisms studied. Only hyperhomocysteinemia (OR 1.17 [95% CI 1.01 to 1.35], P=0.033) and previous myocardial infarction (OR 3.76 [95% CI 1.10 to 12.81], P=0.034) maintained a significant correlation with cIMT on multiple logistic regression analysis. Conclusion: cIMT is increased in patients with hyperhomocysteinemia, inflammation and extended CAD. MTHFR 677 C/T, VEGF -460 C/T, eNOS 894 G/ T, MCP-1 -2518 A/G and ApoE single nucleotide polymorphisms were not associated with increased cIMT. © 2009 Pulsus Group Inc. All rights reserved.
dc.identifier.DOI-ID10.1016/S0828-282X(09)70022-4
dc.identifier.issn0828282X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18909
dc.language.isoEnglish
dc.publisherPulsus Group Inc.
dc.rightsAll Open Access; Green Open Access
dc.subject5,10 methylenetetrahydrofolate reductase (FADH2)
dc.subjectapolipoprotein E
dc.subjectC reactive protein
dc.subjectendothelial nitric oxide synthase
dc.subjecthomocysteine
dc.subjectmonocyte chemotactic protein 1
dc.subjectvasculotropin
dc.subjectadult
dc.subjectamino acid blood level
dc.subjectartery intima proliferation
dc.subjectarticle
dc.subjectcardiovascular risk
dc.subjectcoronary artery atherosclerosis
dc.subjectcoronary artery disease
dc.subjectDNA polymorphism
dc.subjectfemale
dc.subjectgenetic association
dc.subjectgenotype
dc.subjectheart infarction
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectprotein blood level
dc.subjectrestriction fragment length polymorphism
dc.subjectrisk assessment
dc.subjectsingle nucleotide polymorphism
dc.subjectTurkey (republic)
dc.titlePolymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-1 and apolipoprotein E genes are not associated with carotid intima-media thickness
dc.typeArticle

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