Hexagonal Boron Nitride/PCL/PLG Coatings on Borate Bioactive Glass Scaffolds for Bone Regeneration

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dc.contributor.authorEnsoylu M.
dc.contributor.authorDeliormanlı A.M.
dc.contributor.authorAtmaca H.
dc.date.accessioned2024-07-22T08:04:28Z
dc.date.available2024-07-22T08:04:28Z
dc.date.issued2022
dc.description.abstractIn this study, hexagonal boron nitride (hBN) nanoparticle- containing (0.1–2 wt%) polycaprolactone (PCL) and polylactic-co-glycolic acid (PLG)-coated 13-93B3 borate-based porous bioactive glass composite scaffolds were prepared by polymer foam replication method and their ability to use in bone tissue engineering applications was assessed. Morphological, mechanical properties, cytotoxicity and the drug release behavior of the prepared composite scaffolds were investigated. In vitro bioactivity was tested in simulated body fluid and results were analyzed using FTIR spectrometer and SEM. Results showed that both polymer coating and the existence of hBN nanoparticles in the polymeric matrix improved the compressive strength of the fabricated composite scaffolds. Incorporation of the hBN nanoparticles enhanced the in vitro hydroxyapatite forming ability of the glass composites. Results also revealed that prepared bioactive glass based composite scaffolds showed no toxicity to MC3T3-E1 cells under in vitro conditions up to 72 h and hBN-containing glass scaffolds showed higher gentamicin sulfate release rates compared to the bare polymer coated scaffolds. Manufactured bioactive glass scaffolds containing hBN nanoparticles are found to be promising for bone repair and regeneration. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s10904-022-02246-8
dc.identifier.issn15741443
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12702
dc.language.isoEnglish
dc.publisherSpringer
dc.subjectBiomechanics
dc.subjectBody fluids
dc.subjectCompressive strength
dc.subjectControlled drug delivery
dc.subjectFoams
dc.subjectFunctional polymers
dc.subjectHydroxyapatite
dc.subjectMedical applications
dc.subjectNanoparticles
dc.subjectNitrides
dc.subjectPlastic coatings
dc.subjectPolymer matrix composites
dc.subjectScaffolds (biology)
dc.subjectSulfur compounds
dc.subjectTargeted drug delivery
dc.subjectBone regeneration
dc.subjectComposite scaffolds
dc.subjectGlass composites
dc.subjectGlass scaffolds
dc.subjectHexagonal boron nitride
dc.subjectIn-vitro
dc.subjectNitride nanoparticles
dc.subjectPoly lactic-co-glycolic acid
dc.subjectPolymer foams
dc.subjectPorous bioactive glass
dc.subjectBoron nitride
dc.titleHexagonal Boron Nitride/PCL/PLG Coatings on Borate Bioactive Glass Scaffolds for Bone Regeneration
dc.typeArticle

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