Direct Write Assembly of Graphene/Poly(ε-Caprolactone) Composite Scaffolds and Evaluation of Their Biological Performance Using Mouse Bone Marrow Mesenchymal Stem Cells
| dc.contributor.author | Deliormanli, AM | |
| dc.date.accessioned | 2025-04-10T10:26:47Z | |
| dc.date.available | 2025-04-10T10:26:47Z | |
| dc.description.abstract | Scaffold and mesenchymal stem cell-based cartilage tissue engineering offers a favorable way for the repair and regeneration of injured cartilage. In this study, poly (epsilon-caprolactone) PCL scaffolds with grid-like structure having periodic lattice was manufactured by robocasting method in the presence of graphene nanoplatelets for cartilage tissue engineering applications. For this purpose, a PCL solution (20wt%) containing pristine graphene nanopowders in the form of platelets was prepared as printing ink and it was dispensed through a nozzle at room temperature to an ethanol bath at 4 degrees C. The construction of porous scaffolds was made by a layer-by-layer assembly. Results revealed that graphene additions were not detrimental to deposition process and the structure of the resultant scaffolds. In vitro cell tests indicated that the prepared grid-like graphene/PCL composite scaffolds have good cytocompatibility and non-toxicity for mouse bone marrow mesenchymal stem cells. The stem cells attached and proliferated well on the scaffolds and they also demonstrated a chondrogenic differentiation in the absence of transforming growth factors. | |
| dc.identifier.e-issn | 1559-0291 | |
| dc.identifier.issn | 0273-2289 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/34411 | |
| dc.language.iso | English | |
| dc.title | Direct Write Assembly of Graphene/Poly(ε-Caprolactone) Composite Scaffolds and Evaluation of Their Biological Performance Using Mouse Bone Marrow Mesenchymal Stem Cells | |
| dc.type | Article |