Effects of non-dependent lung oxygen insuffation on oxygenation and respiratory mechanics during one-lung ventilation in patients with stage II COPD

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dc.contributor.authorÖztürk T.
dc.contributor.authorAydin D.
dc.contributor.authorYaldiz S.
dc.contributor.authorYuncu G.
dc.contributor.authorAtay A.
dc.contributor.authorSavaci S.
dc.date.accessioned2024-07-22T08:14:16Z
dc.date.available2024-07-22T08:14:16Z
dc.date.issued2015
dc.description.abstractIntroduction: The aim of this study was to investigate the changes on oxygenation, shunt ratio and respiratory mechanics of 6 L/min oxygen insuffation to the non-dependent lung, while extrinsic PEEP (PEEPe, equivalent to the patient's PEEPi) was being applied to the dependent lung in patients undergoing lung surgery. Material and Methods: Patients with stage II COPD undergoing elective lung surgery (n=22) were intubated with a doublelumen endobronchial tube and performed a PA catheterization. One lung ventilation settings were: tidal volume 6 ml/kg, 12 breaths/min, and I: E ratio 1: 2. Procedure was performed in four sequential periods (each period continued for 15 minutes): After frst stabilization period (PEEP0-1), PEEPe (at the level of intrinsic PEEP, PEEPi) was applied in the dependent lung while the non-dependent lung was exposed to air. After second stabilization period (PEEP0-2), the non-dependent lung received 6 L/min oxygen (O2) through a catheter placed into the tube while PEEPe (at the level of PEEPi) was applied in the dependent lung (PEEPe+O2). At the end of each 15 minute period, haemodynamic data, lung compliance (C), airway resistance (R), and PEEPi were recorded and blood gas samples were obtained. Results: PaO2 was signifcantly higher during the PEEPe+O2 period (p<0.001), while Qs/Qt was signifcantly lower in the PEEPe+O2 period when compared with the PEEPe period (p<0.0001). Compliance increased signifcantly during PEEPe compared to PEEP0-1 (p<0.05). Discussion and Conclusion: The insuffation of oxygen to the non-dependent lung with application of PEEPe-equivalent to the patient's PEEPi - to the dependent lung increased oxygenation and decreased Qs/Qt in patients with moderate COPD. We recommend this simple and useful method which does not need extra equipment.
dc.identifier.DOI-ID10.5222/GKDAD.2015.082
dc.identifier.issn13055550
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16533
dc.language.isoEnglish
dc.publisherTurkish Anaesthesiology and Intensive Care Society
dc.subjectadult
dc.subjectair
dc.subjectairway resistance
dc.subjectArticle
dc.subjectblood gas
dc.subjectbreathing mechanics
dc.subjectcatheterization
dc.subjectchronic obstructive lung disease
dc.subjectclinical article
dc.subjectendobronchial intubation
dc.subjectexposure
dc.subjectfemale
dc.subjecthuman
dc.subjectlung compliance
dc.subjectlung hemodynamics
dc.subjectlung surgery
dc.subjectmale
dc.subjectone lung ventilation
dc.subjectoxygen therapy
dc.subjectoxygenation
dc.subjectpositive end expiratory pressure
dc.subjecttidal volume
dc.titleEffects of non-dependent lung oxygen insuffation on oxygenation and respiratory mechanics during one-lung ventilation in patients with stage II COPD
dc.typeArticle

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