Increased vascular surface density in ovarian endometriosis

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dc.contributor.authorInan S.
dc.contributor.authorKuscu N.K.
dc.contributor.authorVatansever S.
dc.contributor.authorOzbilgin K.
dc.contributor.authorKoyuncu F.
dc.contributor.authorSayhan S.
dc.date.accessioned2024-07-22T08:24:59Z
dc.date.available2024-07-22T08:24:59Z
dc.date.issued2003
dc.description.abstractOur goal in this study was to investigate the presence of angiogenesis-related factors in endometriomas by evaluating their vascular surface densities. Thirty ovarian samples were included in the study. Of these, ten were histologically confirmed endometriomas, ten were ovarian specimens in the follicular phase and ten were ovarian specimens in the luteal phase, serving as controls. Histological specimens were immunostained for von Willebrand factor (vWF: factor VIII-related antigen) and CD34. The area with the highest microvessel density in endometriosis and in the normal ovary was evaluated by using an intercept grid. All microvessels in a specific field (x 100 magnification) were counted and vascular surface density was measured, as 164.01 ± 21.26 vs. 125.15 ± 11.28 and 117.44 ± 9.27 by using vWF, and as 172.97 ± 25.64 vs. 138.65 ± 32.21 and 120.34 ± 18.40 by using CD34 in endometriotic, follicular and luteal ovarian samples, respectively (p < 0.001). The mean vascular surface density was significantly higher in endometriosis than in the ovarian samples of the follicular phase or the luteal phase. No significant difference was seen between normal ovarian samples. Endometriosis was associated with angiogenic properties. Having demonstrated elevated angiogenic factors in endometriotic samples, we concluded that activation of angiogenesis might be a key factor in the pathogenesis of endometriosis.
dc.identifier.DOI-ID10.1080/gye.17.2.143.150
dc.identifier.issn09513590
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20211
dc.language.isoEnglish
dc.publisherParthenon Publishing Group Ltd
dc.subjectangiogenic factor
dc.subjectCD34 antigen
dc.subjectvon Willebrand factor
dc.subjectadult
dc.subjectangiogenesis
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectendometriosis
dc.subjectendometrium tumor
dc.subjectfemale
dc.subjectfollicular phase
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectluteal phase
dc.subjectmicrovasculature
dc.subjectovary
dc.subjectpriority journal
dc.subjectprotein function
dc.subjecttumor vascularization
dc.titleIncreased vascular surface density in ovarian endometriosis
dc.typeArticle

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