Effect of monocyte chemoattractant protein-1 (MCP-1) gene polymorphism in Turkish patients with premature coronary artery disease

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dc.contributor.authorCam S.F.
dc.contributor.authorSekuri C.
dc.contributor.authorSagcan A.
dc.contributor.authorErcan E.
dc.contributor.authorTengiz I.
dc.contributor.authorAlioglu E.
dc.contributor.authorBerdeli A.
dc.date.accessioned2024-07-22T08:22:06Z
dc.date.available2024-07-22T08:22:06Z
dc.date.issued2008
dc.description.abstractObjectives. It has been suggested that monocyte chemoattractant protein-1 (MCP-1) is important in the initiation of atherosclerosis and crucial in monocyte recruitment into the subendothelial lesions. Recent studies have demonstrated that MCP-1 -2518 A>G polymorphism is associated with susceptibility to coronary artery disease (CAD). Since there are conflicting reports on the possible association of MCP-1 -2518 A>G polymorphism with CAD, we investigated the role of this polymorphism in Turkish patients with premature CAD. Material and methods. Genomic DNA was collected from 171 premature CAD patients and 151 healthy individuals. MCP-1 -2518 A>G polymorphism was genotyped using the PCR-RFLP method. Results. There were no differences between genotype distribution and allele frequencies in the premature CAD and control groups (AA: 49.7 %; AG: 40.3 %; GG: 10.0 % in premature CAD groups and AA: 53.7 %; AG: 34.4 %; GG: 11.9 % in controls; p = 0.53). The prevalence of the G allele was 0.302 in patients and 0.291 in controls. Conclusions. Our data demonstrate that MCP-1 -2518 A>G polymorphism is not associated with premature CAD in Turkish patients. Further studies are needed to elucidate the role of this polymorphism in the pathogenesis of CAD in various populations. © 2008 Informa UK Ltd (Informa Healthcare, Taylor & Francis AS).
dc.identifier.DOI-ID10.1080/00365510802287257
dc.identifier.issn15027686
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18931
dc.language.isoEnglish
dc.subjectAged
dc.subjectAsian Continental Ancestry Group
dc.subjectCase-Control Studies
dc.subjectChemokine CCL2
dc.subjectCoronary Artery Disease
dc.subjectDemography
dc.subjectEthnic Groups
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Predisposition to Disease
dc.subjectGenotype
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectTurkey
dc.subjectgenomic DNA
dc.subjectmonocyte chemotactic protein 1
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectcoronary artery disease
dc.subjectdemography
dc.subjectDNA polymorphism
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenotype
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectrestriction fragment length polymorphism
dc.subjectTurkey (republic)
dc.titleEffect of monocyte chemoattractant protein-1 (MCP-1) gene polymorphism in Turkish patients with premature coronary artery disease
dc.typeArticle

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