The clinical significance of atrial and brain natriuretic peptides; [Atrial ve beyin natriüretik peptid'in klinik önemi]
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Date
2002
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Abstract
Heart is not only a pump functionally, but also secrets two different significant peptides like an endocrine organ: ANP (Atrial Natruretic Peptide) and BNP (Brain Natriuretic Peptide). Many different effects of these peptides which have structural homology, on heart, kidneys, electrolytes and blood volume were proven. A different peptide, C-type natriuretic peptide, originates from vascular endothelial wall and since it doesn't originate from myocard, it is not mentioned together with others. ANP is secreted from atrium. Although BNP originates from cardiac ventricules, since it was first isolated from brain, it is called brain natriuretic peptide. The changing concentrations of ANP and BNP according to some physiological conditions like posture or effort were measured both in renal failure and after myocardial infarction and also particularly in heart failure. Besides, these findings revealed that the levels of ANP and BNP can be used to follow the clinical status of patients. According to recent studies, BNP can be used as an indicator to predict the prognosis of the patients with both asymptomatic and severe ischemic heart failure.