Does thyroid replacement therapy affect pulmonary function tests in patients with subclinical hypothyroidism?

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dc.contributor.authorKoral L.
dc.contributor.authorHekimsoy Z.
dc.contributor.authorYildirim C.
dc.contributor.authorOzmen B.
dc.contributor.authorYorgancioglu A.
dc.contributor.authorGirgin A.
dc.date.accessioned2024-07-22T08:23:21Z
dc.date.available2024-07-22T08:23:21Z
dc.date.issued2006
dc.description.abstractObjective: Subclinical hypothyroidism is an elevation in serum thyroid-stimulating hormone (TSH) while having normal serum free thyroxine (FT4) and triiodothyronine (FT3) levels. The purpose of this prospective observational study was to evaluate the pulmonary function of patients diagnosed with subclinical hypothyroidism, both before and after treatment with thyroid hormone. Methods: This study took place at the Medical Faculty, Celal Bayar University, Manisa, Turkey between February 2003 and June 2004. Thirty-eight patients (37 females, one male) with subclinical hypothyroidism between 20 and 65 years of age were included in the study. Most were mildly obese. Arterial blood gases and pulmonary function tests were performed before treatment with thyroid hormone, and afterwards, the TSH value reached the normal range (indicating euthyroidism). Results: Oxygen saturation, but not partial oxygen pressure or partial carbon dioxide pressure, was statistically, but not clinically significantly higher after treatment with thyroid hormone (p=0.01). Pulmonary function tests were not significantly different before and after treatment with thyroid hormone. Conclusion: In our subclinical hy pothyroidism patients, pulmonary function tests were normal and did not significantly change with thyroid hormone replacement. The advantages of thyroid hormone replacement therapy, at least regarding respiratory function, seem to be clearly present in patients with overt, clinical hypothyroidism but not in patients with subclinical hypothyroidism.
dc.identifier.issn03795284
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19478
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectHormone Replacement Therapy
dc.subjectHumans
dc.subjectHypothyroidism
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOxygen
dc.subjectProspective Studies
dc.subjectRespiratory Function Tests
dc.subjectThyroxine
dc.subjectlevothyroxine
dc.subjectliothyronine
dc.subjectthyrotropin
dc.subjectthyroxine
dc.subjectadult
dc.subjectaged
dc.subjectarterial gas
dc.subjectarticle
dc.subjectblood sampling
dc.subjectcarbon dioxide tension
dc.subjectchemoluminescence
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectfemale
dc.subjectforced expiratory volume
dc.subjectfree liothyronine index
dc.subjectfree thyroxine index
dc.subjecthuman
dc.subjecthypothyroidism
dc.subjectlung function test
dc.subjectmale
dc.subjectobesity
dc.subjectoxygen saturation
dc.subjectoxygen tension
dc.subjectstatistical analysis
dc.subjectstatistical significance
dc.subjectthyrotropin blood level
dc.subjectTurkey (republic)
dc.titleDoes thyroid replacement therapy affect pulmonary function tests in patients with subclinical hypothyroidism?
dc.typeArticle

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