Features of chronic inflammation at the gastric cardia and the relationship with Helicobacter pylori infection and oesophagitis

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dc.contributor.authorAyhan S.
dc.contributor.authorDemir M.A.
dc.contributor.authorKandiloglu A.R.
dc.contributor.authorSaruc M.
dc.contributor.authorKucukmetin N.
dc.date.accessioned2024-07-22T08:25:02Z
dc.date.available2024-07-22T08:25:02Z
dc.date.issued2003
dc.description.abstractBackground: The etiopathogenesis of chronic inflammation at the gastric cardia is still debated. It is suggested that carditis may be a finding of gastro-oesophageal reflux disease (GORD) or it may occur as a result of the gastritis caused by Helicobacterpylori (H. pylori) infection. Aim: To examine morphological features of carditis, as well as the associations of carditis with Helicobacter pylori gastritis and oesophagitis as a marker of gastro-oesophageal reflux disease. Patients and methods: Endoscopic biopsy specimens obtained systematically from oesophagus, cardia, corpus and antrum of 135 dyspeptic patients were retrospectively evaluated. In biopsies, we have searched for any correlations between clinical, endoscopic, and histological features. Results: Carditis was detected in 123 (91.1%) of the cases. The mean age of the carditis group was 47.9 years and the male-to-female ratio was 1.08:1. The relation of carditis with age and sex was not significant (p = 0.19 and p = 0.24, respectively). All cases of the carditis group had concomitant chronic gastritis. In these cases, chronic inflammation, degree of neutrophil-mediated activity and H. pylori colonisation were significantly correlated in cardia, corpus and antrum (p < 0.001). Intestinal metaplasia was observed in 14 cases (11.3%) and, was associated with H. pylori colonisation (p < 0.001). Microscopic oesophagitis detected in 37.7% cases also showed correlation with reflux symptoms and endoscopic oesophagitis but not carditis. When all cases with carditis were evaluated for H. pylori infection and oesophagitis, which are presumed risk factors for carditis, H. pylori infection appeared to be an independent risk factor for carditis (p = 0.012), while oesophagitis did not. Conclusions: This study suggests that carditis is commonly found in patients presenting with dyspepsia and the histological features of carditis were similar to those seen in H. pylori gastritis in antrum and corpus. In addition, our data have also shown that carditis was significantly associated with H. pylori infection but not with symptoms or signs of GORD.
dc.identifier.issn00015644
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20240
dc.language.isoEnglish
dc.subjectAdult
dc.subjectCardia
dc.subjectChronic Disease
dc.subjectDyspepsia
dc.subjectEsophagitis
dc.subjectFemale
dc.subjectGastritis
dc.subjectGastroesophageal Reflux
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectHumans
dc.subjectIncidence
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRetrospective Studies
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectarticle
dc.subjectbacterial colonization
dc.subjectcardia
dc.subjectcarditis
dc.subjectchronic gastritis
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdisease association
dc.subjectdyspepsia
dc.subjectendoscopic biopsy
dc.subjectesophagitis
dc.subjectesophagus
dc.subjectfemale
dc.subjectgastroesophageal reflux
dc.subjectHelicobacter infection
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectintestine metaplasia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmorphology
dc.subjectneutrophil
dc.subjectnonhuman
dc.subjectrisk factor
dc.subjectsex
dc.subjectsex ratio
dc.subjectstatistical significance
dc.subjectstomach antrum
dc.subjectsymptom
dc.titleFeatures of chronic inflammation at the gastric cardia and the relationship with Helicobacter pylori infection and oesophagitis
dc.typeArticle

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