Comparison of the protective effects of intratympanic dexamethasone and methylprednisolone against cisplatin-induced ototoxicity

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dc.contributor.authorÖzel H.E.
dc.contributor.authorÖzdoʇan F.
dc.contributor.authorGürgen S.G.
dc.contributor.authorEsen E.
dc.contributor.authorGenç S.
dc.contributor.authorSelçuk A.
dc.date.accessioned2024-07-22T08:12:04Z
dc.date.available2024-07-22T08:12:04Z
dc.date.issued2016
dc.description.abstractObjective: This study aimed to compare the efficacies of intratympanic dexamethasone and methylprednisolone in preventing in cisplatin-induced ototoxicity in rats. Methods: Experimental groups of rats (n = 8 each) received intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic dexamethasone, or intraperitoneal cisplatin and intratympanic methylprednisolone. Distortion product otoacoustic emission thresholds were compared on days 0 and 10 in all rats, and correlations between drug effects and changes in cochlear histology were evaluated. Results: Distortion product otoacoustic emission thresholds were comparable in groups III and IV (p > 0.05). Significant protection against cisplatin-induced ototoxicity was seen in groups III and IV compared with group II (p < 0.05). Dexamethasone and, to a lesser extent, methylprednisolone protected against cellular apoptosis in cisplatin-induced ototoxicity. Conclusion: Dexamethasone (and possibly methylprednisolone) may be clinically useful as an intratympanic chemopreventive agent to treat cisplatin ototoxicity. Future clinical studies should investigate the use of dexamethasone for this purpose in adult patients. © JLO (1984) Limited 2016.
dc.identifier.DOI-ID10.1017/S0022215115003473
dc.identifier.issn00222151
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15893
dc.language.isoEnglish
dc.publisherCambridge University Press
dc.subjectAnimals
dc.subjectAntineoplastic Agents
dc.subjectCisplatin
dc.subjectDexamethasone
dc.subjectFemale
dc.subjectHearing Loss, Sensorineural
dc.subjectMethylprednisolone
dc.subjectNeuroprotective Agents
dc.subjectOtoacoustic Emissions, Spontaneous
dc.subjectRandom Allocation
dc.subjectRats, Wistar
dc.subjectcisplatin
dc.subjectdexamethasone
dc.subjectisotonic solution
dc.subjectmethylprednisolone
dc.subjectsodium chloride
dc.subjectantineoplastic agent
dc.subjectcisplatin
dc.subjectdexamethasone
dc.subjectmethylprednisolone
dc.subjectneuroprotective agent
dc.subjectadult
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcochlea
dc.subjectcomparative effectiveness
dc.subjectcontrolled study
dc.subjectcorrelational study
dc.subjectdistortion product otoacoustic emission
dc.subjectdrug effect
dc.subjectfemale
dc.subjecthistopathology
dc.subjectmiddle aged
dc.subjectnonhuman
dc.subjectototoxicity
dc.subjectrat
dc.subjectanimal
dc.subjectchemically induced
dc.subjectHearing Loss, Sensorineural
dc.subjectpathology
dc.subjectphysiology
dc.subjectrandomization
dc.subjectspontaneous otoacoustic emission
dc.subjectWistar rat
dc.titleComparison of the protective effects of intratympanic dexamethasone and methylprednisolone against cisplatin-induced ototoxicity
dc.typeArticle

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