Effects of high-dose rocuronium on the QTc interval during anaesthesia induction in patients undergoing coronary artery bypass graft surgery; [Koroner arter cerrahisi geçirecek olgularda anestezi İndüksiyonu sırasında yüksek doz roküronyumun QTc İntervali üzerine etkileri]
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2014
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Abstract
Objective: Existing myocardial damage in coronary artery disease patients causes prolonged QT syndrome. The primary objective of this trial is to explore the effects of different doses of muscle relaxant agent rocuronium (0.6 mg.kg−1 and 1.2 mg.kg −1) on QTc following anesthetic induction. Seconder objective is to determine the incidence and kinds of arrythmias.; Methods: In this prospective and randomized trial, patients undergo elective coronary arteria revascularisation surgery were included in one of two groups. Both groups took same anesthetic induction agents; midazolam and fentanyl. Rocuronium was administered in Group 1(n=20) with dose of 0.6 mg. kg−1 and in Group 2 (n=20) with dose of 1.2 mg.kg−1 for muscle relaxation.; Heart rate, avarage arteria pressure and QTc were recorded before induction(T0), after induction(T1), after muscle relaxant(T2), 2 minutes(T3) and 5 minutes after entubation(T4).; Results: QTc was significantly long just in 2 minutes after entubation (in Group 1 and Group 2 respectively, 447.9±28.3, 466.1±37.8ms), than those at the beginning (respectively, 426.9±25.7, 432.0±35.5ms)(p<.0.01). In intergroup comparison, avarage QTc values were similar in all trial periods (p>0.05). The prevalance of arrythmias in between Group 1 (35%, n=7), and Group 2 (15%, n=3) were similar (p=0.06). Arrythmias were recorded 2 minutes after entubation in both groups (n=10, 25%).; Conclusion: In patients undergoing coronary arteria revascularisation surgery, rocuronium doses of 0.6 mg kg −1 and 1.2 mg kg −1 had have prolonged the QTc interval after entubation. Cardiac arrthymias related to long QTc arising after entubation should be taken into consideration. © 2014 by Turkish Anaesthesiology and Intensive Care Society.