The effect of recombinant human growth hormone (rhGH) on trinitrobenzene sulfonic acid-induced colitis in rats: An experimental study

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dc.contributor.authorKara E.
dc.contributor.authorSungurtekin H.
dc.contributor.authorSungurtekin U.
dc.contributor.authorAlkanat M.
dc.contributor.authorIlkgul O.
dc.date.accessioned2024-07-22T08:24:30Z
dc.date.available2024-07-22T08:24:30Z
dc.date.issued2004
dc.description.abstractThe limited efficacy of standard medical therapies for inflammatory bowel diseases has resulted in a continuing search for alternative treatments. Growth hormone (GH) has shown to have mutagenic and proliferative effects on intestinal cells. This study was designed to identify the effect of growth hormone on trinitrobenzene slfonic acid-induced colitis (TNBSIC) in rats. This study was carried out on 30 rats, divided in 3 groups: group 1: TNBSIC+ GH, group 2: TNBSIC, group 3: saline enema. Colitis was induced in male Sprague-Dawley rats (200 g-250 g) by intracolonic installation of 2, 4, 6-trinitrobenzene sulphonic acid in 50% ethanol. GH treatment has been started and continued throughout the study after inducing colitis. All rats were killed after 5 weeks and colonic segments were examined histopathologically. Microscopic and macroscopic damage scores were caulculated. Intestinal damage scores were found higher in Goups II when compared with treatment group (P < 0.05). There was no damage in group 3 as expected. Both macroscopic and microscopic scores were highest in group 2 (P < 0.05). The myloperoxidase activity was found lower comparing to group 2 (P < 0.05). In conclusion, growth hormone replacement had protective effects against colonic inflammation while reducing intestinal damage on TNB-induced colitis. Copyright © 2004 by Lippincott Williams & Wilkins.
dc.identifier.DOI-ID10.1097/00054725-200403000-00008
dc.identifier.issn10780998
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19993
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectBiopsy, Needle
dc.subjectColitis, Ulcerative
dc.subjectDisease Models, Animal
dc.subjectHuman Growth Hormone
dc.subjectImmunohistochemistry
dc.subjectIntestinal Mucosa
dc.subjectMale
dc.subjectProbability
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReference Values
dc.subjectSensitivity and Specificity
dc.subjectStatistics, Nonparametric
dc.subjectTrinitrobenzenesulfonic Acid
dc.subjectalcohol
dc.subjectenema
dc.subjecthuman growth hormone
dc.subjectmyeloperoxidase
dc.subjectsaizen 4
dc.subjectsodium chloride
dc.subjecttrinitrobenzenesulfonic acid
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcell proliferation
dc.subjectcolitis
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectenteritis
dc.subjectenzyme activity
dc.subjecthistopathology
dc.subjecthormone substitution
dc.subjectintestine cell
dc.subjectintestine injury
dc.subjectmale
dc.subjectmicroscopy
dc.subjectmutagenesis
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectscoring system
dc.subjecttreatment outcome
dc.titleThe effect of recombinant human growth hormone (rhGH) on trinitrobenzene sulfonic acid-induced colitis in rats: An experimental study
dc.typeArticle

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