Antineuronal antibodies and 8-OHdG an indicator of cerebellar dysfunction in autism spectrum disorder: a case–control study

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dc.contributor.authorKilicaslan F.
dc.contributor.authorAyaydin H.
dc.contributor.authorCelik H.
dc.contributor.authorKutuk M.O.
dc.contributor.authorKandemir H.
dc.contributor.authorKoyuncu I.
dc.contributor.authorKirmit A.
dc.date.accessioned2024-07-22T08:08:20Z
dc.date.available2024-07-22T08:08:20Z
dc.date.issued2019
dc.description.abstractObjectives: Autism spectrum disorder (ASD) is a neurodevelopmental disorder, that starts in early childhood and presents with deficiencies in social-communicational domains along with restricted and repetitive behaviours/interests. While genetic factors are dominant in its pathogenesis, many factors, including neurological, environmental and immunological have been identified. Furtheremore, although cerebellar dysfunction in the etiology of autism has been shown in different studies, the possible causes of the dysfunction and the role of neuroinflammation among these causes have not been clarified yet. Anti-Yo, anti-Hu, anti-Ri and anti-Amphiphysin antibodies have been found to be associated with cerebellar degeneration. The aim of the present study was to compare anti-Yo, anti-Hu, anti-Ri and anti- Amphiphysin antibodies and 8-OHdG values in blood using the ELISA method between ASD patients and healthy children to demonstrate the role of neuroinflammation as a potential cause of cerebellar dysfunction and DNA damage and evaluate the relationship between Childhood Autism Rating Scale (CARS) scores in children diagnosed with ASD and these parameters. Methods: Thirty-five consecutive children between the ages of 3 and 12 referred to the Child and Adolescent Psychiatry Outpatient Clinic of Harran University Hospital and diagnosed with ASD according to the DSM-5 diagnostic criteria were included in the study. The children did not have any chronic physical disorders and were treatment naive. Thirty-three healthy children between the ages of 3 and 12 without any physical or psychiatric disorders were included as the healthy control group. For psychiatric evaluation, a sociodemographic form and to measure the severity of autism, CARS was used. In the study, anti-Yo, anti-Hu, anti-Ri and anti-Amphiphysin antibodies and 8-OHdG values in blood were investigated using the ELISA method. Results: Thirty-five cases with autism (62.9% males) and thirty-three healthy controls (72.7% males) were included in the present study (p = 0.385). The median age was 6.0 in the ASD group and 7.0 in the control group (p = 0.146). Among ASD patients, anti-Ri antibody positivity was detected, while no anti-Ri antibody positivity was found in the control group (p = 0.002). In the ASD group, the anti-Hu and 8-OHdG values were found to be significantly higher than those of the controls (p < 0.001, p = 0.001); no significant difference was found between the ASD and control groups with regard to the anti-Yo and anti-Amphiphysin values (p = 0.113, p = 0.275). Conclusions: The results of the present study suggest that antibodies against cerebellum may be present among children with ASD and DNA damage may occur due to oxidative stress. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/24750573.2019.1674241
dc.identifier.issn24750573
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14352
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd.
dc.rightsAll Open Access; Gold Open Access
dc.subject8 hydroxydeoxyguanosine
dc.subjectamphiphysin
dc.subjectautoantibody
dc.subjectHu antibody
dc.subjectRi antibody
dc.subjectunclassified drug
dc.subjectYo antibody
dc.subjectarea under the curve
dc.subjectArticle
dc.subjectautism
dc.subjectbody mass
dc.subjectcase control study
dc.subjectcerebellum degeneration
dc.subjectchild
dc.subjectchild care
dc.subjectChildhood Autism Rating Scale
dc.subjectclinical article
dc.subjectcommunication disorder
dc.subjectcontrolled study
dc.subjectdemography
dc.subjectdiagnostic test accuracy study
dc.subjectdisease severity
dc.subjectDNA damage
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectgenetic risk
dc.subjectheredity
dc.subjecthuman
dc.subjectintellectual impairment
dc.subjectmale
dc.subjectnervous system inflammation
dc.subjectpredictive value
dc.subjectreceiver operating characteristic
dc.titleAntineuronal antibodies and 8-OHdG an indicator of cerebellar dysfunction in autism spectrum disorder: a case–control study
dc.typeArticle

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