The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia

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dc.contributor.authorStrbian D.
dc.contributor.authorDurukan A.
dc.contributor.authorPitkonen M.
dc.contributor.authorMarinkovic I.
dc.contributor.authorTatlisumak E.
dc.contributor.authorPedrono E.
dc.contributor.authorAbo-Ramadan U.
dc.contributor.authorTatlisumak T.
dc.date.accessioned2024-07-22T08:22:19Z
dc.date.available2024-07-22T08:22:19Z
dc.date.issued2008
dc.description.abstractThe blood-brain barrier (BBB) is the principal regulator of blood-borne substance entry into the brain parenchyma. Therefore, BBB leakage, which leads to cerebral edema and influx of toxic substances, is common in pathological conditions such as cerebral ischemia, inflammation, trauma, and tumors. The leakage of BBB after ischemia-reperfusion injury has long been considered to be biphasic, although a considerable amount of discrepancies as for the timing of the second opening does exist among the studies. This led us to evaluate systematically and quantitatively the dynamics of BBB leakage in a rat model of 90-min ischemia-reperfusion, using gadolinium-enhanced (small molecule) magnetic resonance imaging and fluorescent dye Evans Blue (large molecule). BBB leakage was assessed at the following time points after reperfusion: 25 min, 2, 4, 6, 12, 18, 24, 36, 48, and 72 h, and 1, 2, 3, 4, and 5 weeks. We observed BBB leakage for both gadolinium and Evans Blue as early as 25 min after reperfusion. Thereafter, BBB remained open for up to 3 weeks for Evans Blue and up to 5 weeks for gadolinium. Our results show that BBB leakage after ischemia-reperfusion injury in the rat is continuous and long-lasting, without any closure up to several weeks. This is the first systematic and extensive study fully demonstrating BBB leakage dynamics following transient brain ischemia and the findings are of major clinical and experimental interest. © 2008 IBRO.
dc.identifier.DOI-ID10.1016/j.neuroscience.2008.02.012
dc.identifier.issn03064522
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19028
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectBlood-Brain Barrier
dc.subjectBrain Edema
dc.subjectBrain Ischemia
dc.subjectCerebral Arteries
dc.subjectCerebrovascular Circulation
dc.subjectColoring Agents
dc.subjectDisease Models, Animal
dc.subjectEvans Blue
dc.subjectGadolinium
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReperfusion Injury
dc.subjectTime Factors
dc.subjectEvans blue
dc.subjectgadolinium
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectblood brain barrier
dc.subjectbrain ischemia
dc.subjectcontrolled study
dc.subjectmale
dc.subjectmiddle cerebral artery occlusion
dc.subjectmolecular weight
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance imaging
dc.subjectpriority journal
dc.subjectrat
dc.subjectreperfusion
dc.titleThe blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia
dc.typeArticle

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