The current clinical and geographical situation of cutaneous leishmaniasis based on species identification in Turkey

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dc.contributor.authorÖzbilgin A.
dc.contributor.authorTöz S.
dc.contributor.authorHarman M.
dc.contributor.authorGünaştı Topal S.
dc.contributor.authorUzun S.
dc.contributor.authorOkudan F.
dc.contributor.authorGüngör D.
dc.contributor.authorErat A.
dc.contributor.authorErtabaklar H.
dc.contributor.authorErtuğ S.
dc.contributor.authorGündüz C.
dc.contributor.authorÇavuş İ.
dc.contributor.authorKarakuş M.
dc.contributor.authorÖstan Ural İ.
dc.contributor.authorÖlgen M.K.
dc.contributor.authorKayabaşı Ç.
dc.contributor.authorKurt Ö.
dc.contributor.authorÖzbel Y.
dc.date.accessioned2024-07-22T08:08:42Z
dc.date.available2024-07-22T08:08:42Z
dc.date.issued2019
dc.description.abstractLeishmaniases are a group of vector-borne diseases caused by the members of Leishmania genus, and there are three main clinical forms of the infection as visceral, cutaneous, and mucocutaneous. Cutaneous leishmaniasis is a growing public health problem in Turkey due to increasing detection of autochthonous cases caused by L. major and L. donovani in some regions in addition to Syrian imported cases. For this reason, we aimed to evaluate the current epidemiological situation of CL in the view of causative agents and their geographical distribution throughout Turkey. The samples were collected from 356 CL patients admitted to different centers in 18 provinces between January 2013 and December 2016. Direct microscopy, culture (regular and enriched NNN) and molecular techniques (real-time ITS1 PCR and hsp70 PCR/sequencing) were performed. By molecular techniques, 299, 28, 19 and 10 isolates/clinical samples were identified as L. tropica, L. major, L. infantum and L. donovani, respectively. Most of the patients (65.73%) had one lesion usually on their face/head. Dry-nodular type lesions (n = 291) were mainly associated with L. tropica while L. major was mainly found related to wet-ulcerative ones. Leishmaniasis recidivans was also detected in 2.52% among 356 patients. L. tropica was detected as most widespread species causing CL in Turkey. L. infantum and L. major was also found in one third of the provinces. Enriched NNN culture was worked well for isolating the parasite and 346 isolates were successfully grown and stored in liquid nitrogen. The comparison of all diagnostic techniques showed that the parasitological positivity rate could increase if the combination of direct microscopy and real-time ITS1 PCR is used. Besides well-known anthroponotic L. tropica cases, the increasing detection of CL cases caused by zoonotic species, L. infantum and L. major, is one of the most important findings in the present study. In our opinion to ensure timely and accurate diagnosis, proper treatment and countrywide effective control of CL in Turkey a systematic approach is needed on the base of information about characteristics of lesions and patients and epidemiological features of the disease. © 2018 Elsevier B.V.
dc.identifier.DOI-ID10.1016/j.actatropica.2018.11.001
dc.identifier.issn0001706X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14495
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectGeography
dc.subjectHumans
dc.subjectLeishmania
dc.subjectLeishmaniasis, Cutaneous
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectReal-Time Polymerase Chain Reaction
dc.subjectTurkey
dc.subjectYoung Adult
dc.subjectTurkey
dc.subjectLeishmania donovani
dc.subjectLeishmania infantum
dc.subjectLeishmania major
dc.subjectLeishmania tropica
dc.subjectinternal transcribed spacer 1
dc.subjectliquid nitrogen
dc.subjectaccuracy assessment
dc.subjectdisease control
dc.subjectdisease vector
dc.subjectepidemiology
dc.subjectgeographical distribution
dc.subjectidentification method
dc.subjectleishmaniasis
dc.subjectpublic health
dc.subjectreal time
dc.subjectadolescent
dc.subjectadult
dc.subjectArticle
dc.subjectblood culture
dc.subjectchild
dc.subjectfemale
dc.subjectgeographic distribution
dc.subjecthospital admission
dc.subjecthuman
dc.subjectinfant
dc.subjectLeishmania
dc.subjectLeishmania donovani
dc.subjectLeishmania infantum
dc.subjectLeishmania major
dc.subjectLeishmania recidivans
dc.subjectLeishmania tropica
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmicroscopy
dc.subjectmiddle aged
dc.subjectnewborn
dc.subjectparasite identification
dc.subjectpathogenesis
dc.subjectpolymerase chain reaction
dc.subjectpreschool child
dc.subjectschool child
dc.subjectsequence analysis
dc.subjectskin defect
dc.subjectskin leishmaniasis
dc.subjectskin ulcer
dc.subjectspecies identification
dc.subjectTurkey (republic)
dc.subjectyoung adult
dc.subjectzoonosis
dc.subjectaged
dc.subjectgenetics
dc.subjectgeography
dc.subjectisolation and purification
dc.subjectparasitology
dc.subjectreal time polymerase chain reaction
dc.subjectskin leishmaniasis
dc.subjectturkey (bird)
dc.subjectvery elderly
dc.titleThe current clinical and geographical situation of cutaneous leishmaniasis based on species identification in Turkey
dc.typeArticle

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