The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice
| dc.contributor.author | Inan, SY | |
| dc.contributor.author | Aksu, F | |
| dc.contributor.author | Baysal, F | |
| dc.date.accessioned | 2025-04-10T10:33:21Z | |
| dc.date.available | 2025-04-10T10:33:21Z | |
| dc.description.abstract | The effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shuck reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shuck in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. (C) 2000 Elsevier Science B.V. All rights reserved. | |
| dc.identifier.e-issn | 1879-0712 | |
| dc.identifier.issn | 0014-2999 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/39652 | |
| dc.language.iso | English | |
| dc.title | The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice | |
| dc.type | Article |