Distribution of furin, TNF-α, and TGF-β2 in the endometrium of missed abortion and voluntary first trimester termination case

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dc.contributor.authorOzbilgin K.
dc.contributor.authorTuran A.
dc.contributor.authorKahraman B.
dc.contributor.authorAtay C.
dc.contributor.authorVatansever S.
dc.contributor.authorUluer E.T.
dc.contributor.authorÖzçakir T.
dc.date.accessioned2024-07-22T08:14:13Z
dc.date.available2024-07-22T08:14:13Z
dc.date.issued2015
dc.description.abstractObjective: To identify the role of furin, TNF-a, and TGF-b2 in human missed abortion pathogenesis. STUDY DESIGN: Decidual materials were collected from patients diagnosed with a missed abortion (n=10) (missed abortion group) and from legal voluntary termination cases at ≪ 10 gestational weeks (n=10) (normal pregnancy group). Tissue samples were collected from each group by dilation and curettage under mask anesthesia. For all tissue samples, furin, TNF-α, and TGF-β2 primary antibodies were performed by immunohistochemical staining. The number of stained cells was evaluated by using the H-score technique. Results: In immunohistochemical examination, the immunoreactivities of furin, TNF-α, and TGF-β2 were found to be higher in syncytiotrophoblastic cells in the missed abortion group than in the normal pregnancy group (p<0.005). Additionally, high immunoreactivity of TNF-α and TGF-β2 molecules was established only in cytotrophoblastic cells of missed abortions (p<0.005) in examination at decidual cells of the missed abortion group; furin immunoreactivities were detected higher in the missed abortion group than in the control group, but TNF-α and TGF-β2 immunoreactivity were increased in number in the normal pregnancy group (p<0.005). Conclusion: It is considered that high levels of furin and the 2 furin-related proteins (TNF-α and TGF-β2), which play important roles in proliferation, invasion, migration, differentiation, and survival of cells, may be the reason of proceeding decidualization, placentation, and prevention from abortion, in spite of terminating the fetal life. © Science Printers and Publishers, Inc.
dc.identifier.issn08846812
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16518
dc.language.isoEnglish
dc.publisherScience Printers and Publishers Inc.
dc.subjectAbortion, Induced
dc.subjectAbortion, Missed
dc.subjectAdult
dc.subjectEndometrium
dc.subjectFemale
dc.subjectFurin
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectLymphotoxin-alpha
dc.subjectPregnancy
dc.subjectPregnancy Trimester, First
dc.subjectTumor Necrosis Factor-alpha
dc.subjectYoung Adult
dc.subjectfurin
dc.subjecttransforming growth factor beta2
dc.subjecttumor necrosis factor alpha
dc.subjectfurin
dc.subjectFURIN protein, human
dc.subjectlymphotoxin
dc.subjecttumor necrosis factor alpha
dc.subjecttumor necrosis factor
dc.subjectadult
dc.subjectArticle
dc.subjectcell differentiation
dc.subjectcell invasion
dc.subjectcell migration
dc.subjectcell proliferation
dc.subjectcell survival
dc.subjectcontrolled study
dc.subjectdecidua
dc.subjectdecidualization
dc.subjectdilation and evacuation
dc.subjectendometrium
dc.subjectfemale
dc.subjectfirst trimester pregnancy
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmissed abortion
dc.subjectpathogenesis
dc.subjectpriority journal
dc.subjectprotein localization
dc.subjectreproduction
dc.subjectsyncytiotrophoblast
dc.subjectbiosynthesis
dc.subjectendometrium
dc.subjectfirst trimester pregnancy
dc.subjectinduced abortion
dc.subjectmetabolism
dc.subjectmissed abortion
dc.subjectpregnancy
dc.subjectyoung adult
dc.subjectclinical article
dc.subjectcytotrophoblast
dc.subjectdilatation and curettage
dc.subjectplacenta tissue
dc.subjectpregnancy termination
dc.subjectprotein function
dc.subjectprotein localization
dc.subjectstroma
dc.titleDistribution of furin, TNF-α, and TGF-β2 in the endometrium of missed abortion and voluntary first trimester termination case
dc.typeArticle

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