Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome

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dc.contributor.authorGuvenc Y.
dc.contributor.authorVar A.
dc.contributor.authorGoker A.
dc.contributor.authorKuscu N.K.
dc.date.accessioned2024-07-22T08:11:35Z
dc.date.available2024-07-22T08:11:35Z
dc.date.issued2016
dc.description.abstractObjective: To determine serum chemerin, vaspin and omentin-1 in overweight and normal weight patients with polycystic ovary syndrome (PCOS) and investigate the possible relationship between these adipokines and metabolic syndrome. Methods: This cross sectional study enrolled women with PCOS and healthy women. Serum chemerin, vaspin and omentin-1 were assessed by enzyme-linked immunosorbent assay methods. Results: Forty patients with PCOS and 30 healthy controls were included in the study. In the PCOS group, 18 women were overweight (body mass index [BMI] = 25.0–29.9 kg/m2) and 22 had normal weight (BMI = 18.5–24.9 kg/m2). Chemerin, total cholesterol, dehydroepiandrosterone sulphate and free androgen index (FAI) were significantly higher; and high-density lipoprotein cholesterol and sex hormone binding globulin were significantly lower in overweight PCOS patients compared with normal weight PCOS patients. A positive correlation was found between chemerin and BMI, triglyceride, insulin, homeostatic model assessment of insulin resistance and FAI in the PCOS group. There was no difference in serum chemerin, vaspin and omentin-1 between PCOS patients and healthy controls. Conclusion: Circulating chemerin was increased in overweight compared with normal weight PCOS patients. The most predictive variables for circulating chemerin in PCOS patients were BMI, FAI and age. © 2016, © The Author(s) 2016.
dc.identifier.DOI-ID10.1177/0300060516645421
dc.identifier.issn03000605
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15713
dc.language.isoEnglish
dc.publisherSAGE Publications Ltd
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdult
dc.subjectCase-Control Studies
dc.subjectChemokines
dc.subjectCytokines
dc.subjectFemale
dc.subjectGPI-Linked Proteins
dc.subjectHumans
dc.subjectIntercellular Signaling Peptides and Proteins
dc.subjectLectins
dc.subjectMultivariate Analysis
dc.subjectPolycystic Ovary Syndrome
dc.subjectRegression Analysis
dc.subjectSerpins
dc.subjectadipocytokine
dc.subjectandrogen
dc.subjectchemerin
dc.subjectcholesterol
dc.subjectglucose
dc.subjecthigh density lipoprotein cholesterol
dc.subjecthydroxyprogesterone
dc.subjectinsulin
dc.subjectlow density lipoprotein cholesterol
dc.subjectomentin 1
dc.subjectprasterone sulfate
dc.subjectsex hormone binding globulin
dc.subjecttestosterone
dc.subjecttriacylglycerol
dc.subjectunclassified drug
dc.subjectvaspin
dc.subjectchemerin protein, human
dc.subjectchemokine
dc.subjectcytokine
dc.subjectglycosylphosphatidylinositol anchored protein
dc.subjectITLN1 protein, human
dc.subjectlectin
dc.subjectserine proteinase inhibitor
dc.subjectSERPINA12 protein, human
dc.subjectsignal peptide
dc.subjectadult
dc.subjectArticle
dc.subjectbody mass
dc.subjectbody weight
dc.subjectcholesterol blood level
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdisease association
dc.subjectendocrine function
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectfree androgen index
dc.subjecthormone blood level
dc.subjecthuman
dc.subjectinsulin resistance
dc.subjectmetabolic syndrome X
dc.subjectobesity
dc.subjectovary polycystic disease
dc.subjectpredictive value
dc.subjectprotein blood level
dc.subjecttriacylglycerol blood level
dc.subjectblood
dc.subjectcase control study
dc.subjectmultivariate analysis
dc.subjectovary polycystic disease
dc.subjectregression analysis
dc.titleAssessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome
dc.typeArticle

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