The effect of simvastatin on serum cytokine levels and bone metabolism in postmenopausal subjects: Negative correlation between TNF-α, and anabolic bone parameters

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dc.contributor.authorTikiz C.
dc.contributor.authorÜnlü Z.
dc.contributor.authorTikiz H.
dc.contributor.authorAy K.
dc.contributor.authorAngin A.
dc.contributor.authorOnur E.
dc.contributor.authorVar A.
dc.contributor.authorTüzün Ç.
dc.date.accessioned2024-07-22T08:24:36Z
dc.date.available2024-07-22T08:24:36Z
dc.date.issued2004
dc.description.abstractIn this prospective study, we aimed to evaluate the effect of simvastatin on bone metabolism and the correlation between changes in bone turnover parameters and serum cytokine levels. For this purpose, 38 postmenopausal subjects with hypercholesterolemia (>240mg/dl), not on osteoporosis treatment, were studied. Simvastatin was started at a dose of 20mg daily and continued for 3 months. Six patients were excluded from the study during the follow-up period. Pre- and post-treatment samples were analyzed for bone alkaline phosphatase (BAP) and osteocalcin (OCL), as markers of bone formation; for carboxyterminal telopeptide of collagen I (CTX), as a marker of bone resorption; and for interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) cytokine levels. Total cholesterol level was decreased from 262.1 ± 30.9 to 210.2 ± 35.6mg/dl after simvastatin treatment (P < 0.0001). While no significant change was observed in serum CTX level, BAP and OCL levels were significantly increased (from 120.8 ± 56.6 to 149.5 ± 57.6 IU/I [P = 0.008], and from 20.8 ± 12.6 to 34.7 ± 18.4 μg/l [P = 0.015], respectively). In the analysis of cytokines, while no significant change was observed in IL-6 levels, the TNF-α level was found to be significantly decreased after simvastatin treatment (from 77.9 ± 31.6 pg/ml to 23.5 ± 12.6 pg/ml [P = 0.021]). Individual changes in TNF-α levels showed a moderate negative correlation with the individual changes in BAP and OCL levels (r = -0.550 [P = 0.001], and r = -0.497 [P = 0.004], respectively). In conclusion; 20-mg daily simvastatin treatment for 3 months significantly increased BAP and OCL levels (markers of bone formation) in hypercholesterolemic postmenopausal subjects, without affecting bone resorption. These findings support the idea that simvastatin has an anabolic effect on bone formation. Additionally, the presence of a negative correlation between TNF-α levels and the anabolic bone parameters suggests that a cytokine-lowering effect of simvastatin may also be involved in the remodeling process and could exert some additive beneficial effect on bone metabolism.
dc.identifier.DOI-ID10.1007/s00774-004-0496-0
dc.identifier.issn09148779
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20050
dc.language.isoEnglish
dc.publisherSpringer Japan
dc.subjectbiochemical marker
dc.subjectcarboxy terminal telopeptide
dc.subjectcollagen type 1
dc.subjectcytokine
dc.subjectsimvastatin
dc.subjecttumor necrosis factor alpha
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectblood sampling
dc.subjectbone metabolism
dc.subjectbone turnover
dc.subjectclinical article
dc.subjectdrug blood level
dc.subjectdrug effect
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjecthypercholesterolemia
dc.subjectosteoclast
dc.subjectpostmenopause
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectrisk benefit analysis
dc.titleThe effect of simvastatin on serum cytokine levels and bone metabolism in postmenopausal subjects: Negative correlation between TNF-α, and anabolic bone parameters
dc.typeArticle

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