Lymphovascular space invasion and cervical stromal invasion are independent risk factors for nodal metastasis in endometrioid endometrial cancer

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dc.contributor.authorSolmaz U.
dc.contributor.authorMat E.
dc.contributor.authorDereli M.
dc.contributor.authorTuran V.
dc.contributor.authorGungorduk K.
dc.contributor.authorHasdemir P.
dc.contributor.authorTosun G.
dc.contributor.authorDogan A.
dc.contributor.authorOzdemir A.
dc.contributor.authorAdiyeke M.
dc.contributor.authorSanci M.
dc.date.accessioned2024-07-22T08:14:02Z
dc.date.available2024-07-22T08:14:02Z
dc.date.issued2015
dc.description.abstractAims: The purpose of this study was to investigate the potential roles of pathological variables in the prediction of nodal metastasis in women with endometrioid endometrial cancer (EC). Materials and Methods: Women who underwent surgery for endometrioid EC between 1995 and 2012 were retrospectively reviewed. Those who underwent prior neoadjuvant chemotherapy or radiotherapy and inadequate lymphadenectomy as well as those with nonendometrioid histology, synchronous cancers, International Federation of Gynecology and Obstetrics stage IV disease, gross uterine serosal and/or gross adnexal involvement were excluded. Lymph node dissemination was defined as occurring in the following circumstances: (i) when nodal metastasis with pelvic and/or para-aortic (P/PA) lymph node dissection (LND) was performed or (ii) when there was recurrence in the P/PA lymph nodes after a negative LND or when LND was not performed. Univariate and multivariate logistic regression models were used to identify the pathological predictors of lymphatic dissemination. Results: A total of 827 women with endometrioid EC were assessed; 516 (62.4%) of whom underwent P/PA LND and 205 (24.8%) underwent P LND. Sixty-seven (13%) women in the P/PA LND group and 5 (2.4%) in the P LND group had positive lymph nodes. Multivariate analysis confirmed cervical stromal invasion (OR 4.04, 95% CI 2.02-8.07 (P < 0.001)) and lymphovascular space invasion (LVSI) (OR 110.18, 95% CI 38.43-315.87 (P < 0.001)) as independent predictors of lymphatic dissemination. Conclusion: Cervical stromal invasion and LVSI are highly associated with LN metastasis. These markers may serve as a surrogate for nodal metastasis. © 2015 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
dc.identifier.DOI-ID10.1111/ajo.12321
dc.identifier.issn00048666
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16470
dc.language.isoEnglish
dc.publisherBlackwell Publishing
dc.subjectAged
dc.subjectAorta
dc.subjectBlood Vessels
dc.subjectCarcinoma, Endometrioid
dc.subjectCervix Uteri
dc.subjectEndometrial Neoplasms
dc.subjectFemale
dc.subjectHumans
dc.subjectLymph Node Excision
dc.subjectLymphatic Metastasis
dc.subjectLymphatic Vessels
dc.subjectMiddle Aged
dc.subjectNeoplasm Invasiveness
dc.subjectPelvis
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectadult
dc.subjectArticle
dc.subjectcancer adjuvant therapy
dc.subjectcancer recurrence
dc.subjectcervical stromal invasion
dc.subjectendometrioid endometrial cancer
dc.subjectendometrium cancer
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectlymph node dissection
dc.subjectlymph node metastasis
dc.subjectlymphovascular space invasion
dc.subjectmajor clinical study
dc.subjectmedical record review
dc.subjectoverall survival
dc.subjectparaaortic lymph node
dc.subjectpelvis lymph node
dc.subjectpriority journal
dc.subjectprogression free survival
dc.subjecttumor invasion
dc.subjectaged
dc.subjectaorta
dc.subjectblood vessel
dc.subjectCarcinoma, Endometrioid
dc.subjectEndometrial Neoplasms
dc.subjectlymph node dissection
dc.subjectlymph node metastasis
dc.subjectlymph vessel
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectpelvis
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectsecondary
dc.subjecttumor invasion
dc.subjectuterine cervix
dc.titleLymphovascular space invasion and cervical stromal invasion are independent risk factors for nodal metastasis in endometrioid endometrial cancer
dc.typeArticle

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