Changes in the levels of endothelium-derived coagulation parameters in nonalcoholic fatty liver disease
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2014
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Abstract
In a majority of patients with nonalcoholic fatty liver disease (NAFLD), cardiovascular risk factors including diabetes mellitus type 2, abdominal obesity, and metabolic syndrome are present. The purpose of this study is to investigate the presence of endothelial injury and the changes in coagulation parameters in NAFLD patients. For this purpose, plasma levels of von Willebrand factor (vWF), thrombomodulin, urokinase plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor pathway inhibitor (TFPI) in patients with NAFLD were measured. There was a significant difference in vWF and TFPI levels between patient and control groups (P<0.05). However, no statistically significant difference was obtained in PAI-1, uPA, and thrombomodulin levels between the two groups (P>0.05). According to our results, an increase in vWF and TFPI levels indicates an endothelial injury in NAFLD cases. © 2014 Wolters Kluwer Health.