Serum levels of spexin are increased in the third trimester pregnancy with gestational diabetes mellitus

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dc.contributor.authorAkbas M.
dc.contributor.authorKoyuncu F.M.
dc.contributor.authorOludag Mete T.
dc.contributor.authorTaneli F.
dc.contributor.authorOzdemir H.
dc.contributor.authorYilmaz O.
dc.date.accessioned2024-07-22T08:08:12Z
dc.date.available2024-07-22T08:08:12Z
dc.date.issued2019
dc.description.abstractSpexin is a peptide that is involved in energy homeostasis and its expression is influenced by altered glucose metabolism. Gestational diabetes mellitus (GDM) is associated with increased insulin resistance (IR) and pregnancy is a progressive insulin resistant state. We hypothesized that spexin may have an effect on the pathophysiology of GDM which further could help to identify the disease. The aim of this study was to investigate spexin levels in the third trimester pregnancies with GDM and healthy controls. Thirty-nine women with GDM and 39 healthy singleton pregnancies were enrolled in this case-control study. Serum spexin concentrations were measured and correlated to biochemical and clinical parameters. Serum spexin levels were significantly higher in women with GDM (3686.25 ± 348.37 vs. 3472.33 ± 293.93 pg/ml, p=.004). Spexin levels ​​did not differ significantly according to treatment modality. Moreover, spexin levels were significantly positively correlated with homeostasis model assessment of IR (HOMA-IR). Spexin levels were significantly higher in women with GDM and closely related to HOMA-IR in the third trimester pregnancy. This may help to better clarify the pathophysiological role of spexin in GDM. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/09513590.2019.1616690
dc.identifier.issn09513590
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14288
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd
dc.subjectAdult
dc.subjectCase-Control Studies
dc.subjectDiabetes, Gestational
dc.subjectFemale
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectPeptide Hormones
dc.subjectPregnancy
dc.subjectPregnancy Trimester, Third
dc.subjectYoung Adult
dc.subjectglucose
dc.subjecthemoglobin A1c
dc.subjectinsulin
dc.subjectpeptide
dc.subjectspexin
dc.subjectunclassified drug
dc.subjectpeptide hormone
dc.subjectSPX protein, human
dc.subjectadult
dc.subjectArticle
dc.subjectcase control study
dc.subjectCaucasian
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthemoglobin blood level
dc.subjecthomeostasis model assessment
dc.subjecthuman
dc.subjectinsulin blood level
dc.subjectmajor clinical study
dc.subjectpregnancy diabetes mellitus
dc.subjectpregnant woman
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectthird trimester pregnancy
dc.subjectblood
dc.subjectinsulin resistance
dc.subjectpregnancy
dc.subjectpregnancy diabetes mellitus
dc.subjectthird trimester pregnancy
dc.subjectyoung adult
dc.titleSerum levels of spexin are increased in the third trimester pregnancy with gestational diabetes mellitus
dc.typeArticle

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