The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study

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dc.contributor.authorTanyeri G.
dc.contributor.authorCelik O.
dc.contributor.authorErbas O.
dc.contributor.authorOltulu F.
dc.contributor.authorYilmaz Dilsiz O.
dc.date.accessioned2024-07-22T08:12:38Z
dc.date.available2024-07-22T08:12:38Z
dc.date.issued2015
dc.description.abstractObjectives/Hypothesis To examine and compare the neuroprotective effects of dexamethasone, oxytocin, and resveratrol administration on regeneration after facial nerve crush injury in a rat model. Study Design Prospective, randomized, controlled animal study. Methods A crush-type facial nerve injury was performed on the right side of all rats (injury group [IG]), whereas there was no injury on the left side (sham group [SG]). These main groups were divided into five subgroups: 1) no medicine (control); 2) physiological serum; 3) dexamethasone; 4) oxytocin; and 5) resveratrol (Res) administered (intraperitoneal injection) for 28 days. Functional recovery was evaluated by daily eye-blink reflex and facial electromyography. Nerve-muscle degeneration and regeneration, apoptosis, and intercellular connections were evaluated in histopathological and immunohistochemical examinations. Results Recovery time of the postinjury eye-blink reflex demonstrated faster recovery in IG + Res when compared with the other subgroups. In peak-to-peak amplitude values, a significant increase was observed in the dexamethasone (P = 0.007) and oxytocin subgroups (P = 0.004) and was even more apparent in the resveratrol subgroup (P < 0.001). Nerve regeneration is apparent in the resveratrol subgroup. Apoptotic changes were evaluated immunohistochemically with TUNEL and Caspase 3 and 6 antibodies staining. Caspase 3 and 6 immunoexpressions of resveratrol and oxytocin subgroups were moderate when compared with dexamethasone subgroup. Except for the resveratrol subgroup, which had an increase in expression, the majority of subgroups were similar to SG in terms of intercellular connections (Connexin 32 and 43). Conclusion Resveratrol leads to the best outcome after facial nerve crush injury in rats when compared with dexamethasone and oxytocin, even though these agents demonstrate a significant improvement in facial nerve regeneration. Level of Evidence N/A. Laryngoscope, 125:E356-E364, 2015 © 2015 The American Laryngological, Rhinological and Otological Society, Inc.
dc.identifier.DOI-ID10.1002/lary.25554
dc.identifier.issn0023852X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16132
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc.
dc.subjectAnimals
dc.subjectCaspase 3
dc.subjectCaspase 6
dc.subjectDexamethasone
dc.subjectElectrophysiology
dc.subjectFacial Nerve Injuries
dc.subjectImmunohistochemistry
dc.subjectIn Situ Nick-End Labeling
dc.subjectNerve Regeneration
dc.subjectNeuroprotective Agents
dc.subjectOxytocin
dc.subjectProspective Studies
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectStilbenes
dc.subjectcaspase 3
dc.subjectcaspase 6
dc.subjectconnexin 32
dc.subjectconnexin 43
dc.subjectdexamethasone
dc.subjectoxytocin
dc.subjectresveratrol
dc.subjectcaspase 3
dc.subjectcaspase 6
dc.subjectdexamethasone
dc.subjectneuroprotective agent
dc.subjectoxytocin
dc.subjectresveratrol
dc.subjectstilbene derivative
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectConference Paper
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectelectromyography
dc.subjectelectrophysiology
dc.subjecteyelid reflex
dc.subjectfacial nerve injury
dc.subjectfunctional assessment
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectnerve regeneration
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectrat
dc.subjectTUNEL assay
dc.subjectanimal
dc.subjectcomparative study
dc.subjectdrug effects
dc.subjectFacial Nerve Injuries
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectprospective study
dc.subjectrandomized controlled trial
dc.subjectSprague Dawley rat
dc.titleThe effectiveness of different neuroprotective agents in facial nerve injury: An experimental study
dc.typeConference paper

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