Prognostic value of serum pregnancy-associated plasma protein A level at the initial ED presentation in elderly patients with CAP

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dc.contributor.authorGolcuk Y.
dc.contributor.authorGolcuk B.
dc.contributor.authorBilge A.
dc.contributor.authorKorkmaz A.
dc.contributor.authorIrik M.
dc.contributor.authorHayran M.
dc.contributor.authorOzdemir A.T.
dc.contributor.authorKurtulmus Y.
dc.date.accessioned2024-07-22T08:12:56Z
dc.date.available2024-07-22T08:12:56Z
dc.date.issued2015
dc.description.abstractObjective This study aims to compare serum pregnancy-associated plasma protein A (PAPP-A) levels in surviving and nonsurviving elderly patients with community-acquired pneumonia (CAP), investigating whether PAPP-A is correlated with CAP prediction scores and whether PAPP-A can successfully predict 28-day mortality rates in elderly patients. Methods This prospective, observational, single-center, cross-sectional study was conducted at the emergency department (ED) of Celal Bayar University Hospital in Manisa, Turkey, between January and September 2014. All patients underwent follow-up evaluations 28 days after admission. The end point was defined as all-cause mortality. Results A total of 100 elderly patients (mean age, 77.3 ± 7.6 years [range, 65-94 years]); 60% men) with CAP were enrolled in this study. All-cause mortality at the 28-day follow-up evaluation was 22%. Admission PAPP-A levels were significantly higher in nonsurvivors compared with 28-day survivors (10.3 ± 4.5 vs 3.8 ± 2.6 ng/mL, P <.001). A significant and positive correlation between admission PAPP-A levels and pneumonia severity index; confusion, oxygen saturation, respiratory rate, blood pressure, and age 75 years or older; and confusion, urea, respiratory rate, blood pressure, and age older than 65 years scores was found (r =.440, P <.001; r =.395, P <.001; and r =.359, P <.001, respectively). Moreover, we determined that the optimal PAPP-A cutoff for predicting 28-day mortality at the time of ED admission was 5.1 ng/mL, with 77.3% sensitivity and 77.9% specificity. Conclusions Serum PAPP-A level is valuable for predicting mortality and the severity of the disease among elderly patients with CAP at ED admission. Thus, PAPP-A might play a further role in the clinical assessment of the severity of CAP. © 2015 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.ajem.2015.05.047
dc.identifier.issn07356757
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16227
dc.language.isoEnglish
dc.publisherW.B. Saunders
dc.subjectAge Factors
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCommunity-Acquired Infections
dc.subjectCross-Sectional Studies
dc.subjectEmergency Service, Hospital
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPneumonia
dc.subjectPredictive Value of Tests
dc.subjectPregnancy-Associated Plasma Protein-A
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectRisk Factors
dc.subjectROC Curve
dc.subjectSurvival Rate
dc.subjectcreatinine
dc.subjectpregnancy associated plasma protein A
dc.subjecturea
dc.subjectpregnancy associated plasma protein A
dc.subjectage
dc.subjectaged
dc.subjectArticle
dc.subjectblood pressure
dc.subjectbreathing rate
dc.subjectchronic lung disease
dc.subjectcommunity acquired pneumonia
dc.subjectcomorbidity
dc.subjectconfusion
dc.subjectcreatinine blood level
dc.subjectcross-sectional study
dc.subjectemergency ward
dc.subjectfemale
dc.subjectfollow up
dc.subjectgeriatric disorder
dc.subjectgeriatric patient
dc.subjectheart disease
dc.subjecthuman
dc.subjectlung ventilation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmalignant neoplastic disease
dc.subjectobservational study
dc.subjectoxygen saturation
dc.subjectPneumonia Severity Index
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectprospective study
dc.subjectprotein blood level
dc.subjectsurvival time
dc.subjectsurvivor
dc.subjectthrombocyte volume
dc.subjecturea blood level
dc.subjecturea nitrogen blood level
dc.subjectblood
dc.subjectCommunity-Acquired Infections
dc.subjectemergency health service
dc.subjectmetabolism
dc.subjectmortality
dc.subjectpneumonia
dc.subjectpredictive value
dc.subjectprognosis
dc.subjectreceiver operating characteristic
dc.subjectrisk factor
dc.subjectsurvival rate
dc.subjectvery elderly
dc.titlePrognostic value of serum pregnancy-associated plasma protein A level at the initial ED presentation in elderly patients with CAP
dc.typeArticle

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