Evidence against the fecal-oral route of transmission for Helicobacter pylori infection in childhood

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dc.contributor.authorTosun S.Y.
dc.contributor.authorKasirga E.
dc.contributor.authorErtan P.
dc.contributor.authorAksu S.
dc.date.accessioned2024-07-22T08:24:43Z
dc.date.available2024-07-22T08:24:43Z
dc.date.issued2003
dc.description.abstractBackground: Acquisition of Helicobacter pylori (H. pylori) occurs mainly in childhood. However, little is known about the mode of transmission. In such developing countries as Turkey, where the hygienic situation facilitates the transmission of hepatitis A virus (HAV), infection with HAV is mainly transmitted via the enteral route. Therefore, it seemed advisable to evaluate the role of fecal-oral transmission in the spread of H. pylori. Material/Methods: Blood samples taken from healthy children (n = 90) 2-16 years old were studied for anti-H. pylori and anti-hepatitis A antibodies by enzyme immunoassay. Results: Of the 90 children, 33.3% were seropositive for both H. pylori and HAV, 33.3% were seronegative for both, 8.9% were seropositive for H. pylori only, and 24.4% were seropositive for HAV only. The percentage of seropositive children increased with age for H. pylori and HAV. There was no significant relationship in seroprevalence between H. pylori and HAV when analyzed by logistic regression analysis (p 0.178). Conclusions: This study suggests that the seropositivity rates of H. pylori and HAV increase with age, while the fecal-oral route may not be an important mode of transmission for H. pylori in children living in western Anatolia, in the Manisa region.
dc.identifier.issn12341010
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20080
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFeces
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectHepatitis A virus
dc.subjectHumans
dc.subjectRegression Analysis
dc.subjectTurkey
dc.subjectbacterium antibody
dc.subjectHelicobacter pylori antibody
dc.subjecthepatitis A antibody
dc.subjectunclassified drug
dc.subjectadolescent
dc.subjectage
dc.subjectantibody detection
dc.subjectarticle
dc.subjectbacterial transmission
dc.subjectblood sampling
dc.subjectchild
dc.subjectcontrolled study
dc.subjectenzyme immunoassay
dc.subjectfemale
dc.subjectHelicobacter infection
dc.subjectHelicobacter pylori
dc.subjecthepatitis A
dc.subjectHepatitis A virus
dc.subjecthuman
dc.subjectlogistic regression analysis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectseroprevalence
dc.subjectTurkey (republic)
dc.titleEvidence against the fecal-oral route of transmission for Helicobacter pylori infection in childhood
dc.typeArticle

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