Diffusion-weighted MR imaging of the breast: Comparison of apparent diffusion coefficient values of normal breast tissue with benign and malignant breast lesions

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dc.contributor.authorOrguc S.
dc.contributor.authorBasara I.
dc.contributor.authorCoskun T.
dc.date.accessioned2024-07-22T08:19:41Z
dc.date.available2024-07-22T08:19:41Z
dc.date.issued2012
dc.description.abstractIntroduction The specificity of conventional magnetic resonance (MR) imaging is lower than its high sensitivity. Diffusion-weighted imaging (DWI), based on alterations in the microscopic motion of water molecules, promises improved specificity for breast MR imaging. In this study, we aimed to determine the diagnostic potential of DWI to differentiate between benign and malignant breast lesions and normal breast tissue. Methods Dynamic contrast-enhanced breast MR imaging and DWI were applied to 108 women. Apparent diffusion coefficient (ADC) values were obtained for normal breast tissue (n = 183), benign lesions (n = 66) and malignant lesions (n = 58). The results were compared with the patients' final diagnoses. Resu lts Mean ADC values for benign and malignant breast lesions were 1.04 × 10-3 ± 0.29 × 10-3 mm2/s and 2.00 × 10-3 ± 0.55 × 10-3 mm2/s, respectively (p = 0.001, Student's t-test), while that for normal breast tissue was 1.78 × 10-3 ± 0.33 × 10-3 mm2/s. With a cut-off value of 1.46 × 10-3 mm2/s for ADC in receiver operating characteristic analysis, 95% sensitivity and 85% specificity were achieved for differentiating between benign and malignant lesions. Conclusion DWI of the breast can help differentiate benign and malignant breast lesions from normal breast tissue. DWI, which can be easily introduced into standard breast MR imaging protocols without increasing imaging times, promises to increase the accuracy of breast MR imaging without contrast media. However, its clinical value will depend on the standardisation of b-values and other technical parameters in larger future study series.
dc.identifier.issn00375675
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17780
dc.language.isoEnglish
dc.publisherSingapore Medical Association
dc.subjectadjuvant chemotherapy
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectatypical ductal hyperplasia
dc.subjectbreast carcinoma
dc.subjectbreast fibroadenoma
dc.subjectbreast lesion
dc.subjectbreast papilloma
dc.subjectcancer invasion
dc.subjectcontrolled study
dc.subjectcystosarcoma phylloides
dc.subjectdiagnostic test accuracy study
dc.subjectdiffusion coefficient
dc.subjectdiffusion weighted imaging
dc.subjectfat necrosis
dc.subjectfemale
dc.subjectgranulomatous mastitis
dc.subjecthematoma
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmastectomy
dc.subjectmedullary carcinoma
dc.subjectneedle biopsy
dc.subjectprospective study
dc.titleDiffusion-weighted MR imaging of the breast: Comparison of apparent diffusion coefficient values of normal breast tissue with benign and malignant breast lesions
dc.typeArticle

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