Relationship between ghrelin and obestatin levels and ghrelin/obestatin ratio in patients with asthma; [Serum ghrelin, obestatin düzeyleri ve ghrelin/obestatin oranının astım ile ilişkisi]

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dc.contributor.authorKizilirmak D.
dc.contributor.authorBozkurt B.
dc.contributor.authorKaramanli H.
dc.date.accessioned2024-07-22T08:08:04Z
dc.date.available2024-07-22T08:08:04Z
dc.date.issued2020
dc.description.abstractMethods: 51 patients with stable persistent asthma and 36 healthy controls were included to the study. Pulmonary function tests were conducted in all case. Skin prick test and an asthma control test were conducted in patients with asthma. All patients and controls were compared in terms of ghrelin and obestatin levels, as well as the ghrelin/obestatin ratio. Plasma concentrations of ghrelin and obestatin were detected by enzymelinked immunosorbent assay. Homeostasis model assessment-insulin resistance (HOMA-IR) scores were calculated as an index of insulin resistance. Results: No differences in ghrelin or obestatin levels or the ghrelin/obestatin ratio were detected between patients with asthma and the control group. Ghrelin levels were significantly lower in obese patients. The HOMA-IR score was significantly higher in patients with asthma than in controls. Conclusion: Ghrelin and obestatin levels, and the ghrelin/obestatin ratio, were similar in controls and patients with stable asthma. Although the groups were similar in terms of body mass index and waist circumference, the HOMA-IR score was significantly higher in patients with asthma. © 2020 by Tuberculosis and Thorax.
dc.identifier.DOI-ID10.5578/tt.68815
dc.identifier.issn04941373
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14243
dc.language.isoEnglish
dc.publisherAnkara University
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdult
dc.subjectAsthma
dc.subjectBiomarkers
dc.subjectBody Mass Index
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectGhrelin
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectRisk Factors
dc.subjectC reactive protein
dc.subjectghrelin
dc.subjectobestatin
dc.subjectbiological marker
dc.subjectghrelin
dc.subjectobestatin, human
dc.subjectadult
dc.subjectallergy test
dc.subjectArticle
dc.subjectasthma
dc.subjectblood sampling
dc.subjectbody height
dc.subjectbody mass
dc.subjectbody weight
dc.subjectcaloric intake
dc.subjectcontrolled study
dc.subjectenzyme assay
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectfood intake
dc.subjectforced expiratory volume
dc.subjectforced vital capacity
dc.subjectglucose blood level
dc.subjecthomeostasis model assessment
dc.subjecthuman
dc.subjectlung function
dc.subjectlung function test
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmean platelet volume
dc.subjectobesity
dc.subjectprick test
dc.subjectwaist circumference
dc.subjectasthma
dc.subjectblood
dc.subjectcase control study
dc.subjectinsulin resistance
dc.subjectmiddle aged
dc.subjectpathophysiology
dc.subjectrisk factor
dc.titleRelationship between ghrelin and obestatin levels and ghrelin/obestatin ratio in patients with asthma; [Serum ghrelin, obestatin düzeyleri ve ghrelin/obestatin oranının astım ile ilişkisi]
dc.typeArticle

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