Melatonin and L-carnitin improves endothelial disfunction and oxidative stress in Type 2 diabetic rats

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dc.contributor.authorSalmanoglu D.S.
dc.contributor.authorGurpinar T.
dc.contributor.authorVural K.
dc.contributor.authorEkerbicer N.
dc.contributor.authorDariverenli E.
dc.contributor.authorVar A.
dc.date.accessioned2024-07-22T08:11:41Z
dc.date.available2024-07-22T08:11:41Z
dc.date.issued2016
dc.description.abstractVascular dysfunction is thought to play a major role in the development of diabetic cardiovascular disease. The roles of endothelial dysfunction, oxidative stress, and dyslipidemia will be considered. Melatonin as well as L-carnitine were shown to possess strong antioxidant properties. Diabetes induced with high fat diet (for 8 weeks) and multipl low doses intraperitoneal injection of STZ (twice, 30. mg/kg/d i.p). The diabetic animals were randomly assigned to one of the experimental groups as follows: Control group (C), high fat diet (HFD), STZ-induced diabetic group (HFD+STZ) , HFD+STZ diabetic group received melatonin (10 mg/kg/d i.p), HFD+STZ diabetic group received L-carnitine (0.6 g/kg/d i.p), and HFD+STZ diabetic group received glibenclamide (5 mg/kg/d, oral). The serum fasting blood glucose, insulin, total cholesterol, HDL- cholesterol, LDL-cholesterol, triglyceride and malondialdehyde (MDA) levels were tested. Acetylcholine induced endothelium-dependent relaxation and sodium nitroprusside induced endothelium-independent relaxation were measured in aortas for estimating endothelial function. Also, glutathione peroxidase (GP x), superoxide dismutase (SOD) and nitric oxide (NO) levels activities were determined in rat liver. According to our results melatonin and L-carnitine treatment decreased fasting blood glucose, total cholesterol, and LDL levels. MDA levels significantly decreased with the melatonin treatment whereas SOD levels were not significantly changed between the groups. The results suggest that especially melatonin restores the vascular responses and endothelial dysfunction in diabetes. © 2015 The Authors.
dc.identifier.DOI-ID10.1016/j.redox.2015.11.007
dc.identifier.issn22132317
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15751
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectCarnitine
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDiet, High-Fat
dc.subjectDyslipidemias
dc.subjectEndothelium, Vascular
dc.subjectGlutathione Peroxidase
dc.subjectHumans
dc.subjectLiver
dc.subjectMelatonin
dc.subjectNitric Oxide
dc.subjectOxidative Stress
dc.subjectRats
dc.subjectSuperoxide Dismutase
dc.subjectTriglycerides
dc.subjectacetylcholine
dc.subjectcarnitine
dc.subjectglibenclamide
dc.subjectglucose
dc.subjectglutathione peroxidase
dc.subjecthigh density lipoprotein cholesterol
dc.subjectinsulin
dc.subjectlow density lipoprotein cholesterol
dc.subjectmalonaldehyde
dc.subjectmelatonin
dc.subjectnitric oxide
dc.subjectnitroprusside sodium
dc.subjectsuperoxide dismutase
dc.subjecttriacylglycerol
dc.subjectantioxidant
dc.subjectcarnitine
dc.subjectglutathione peroxidase
dc.subjectmelatonin
dc.subjectnitric oxide
dc.subjectsuperoxide dismutase
dc.subjecttriacylglycerol
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectdiet restriction
dc.subjectendothelial dysfunction
dc.subjectenzyme blood level
dc.subjectglucose blood level
dc.subjectinsulin blood level
dc.subjectlipid diet
dc.subjectlipid peroxidation
dc.subjectmale
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectrat
dc.subjectstreptozotocin-induced diabetes mellitus
dc.subjectvasodilatation
dc.subjectanimal
dc.subjectblood
dc.subjectdrug effects
dc.subjectdyslipidemia
dc.subjectenzymology
dc.subjectexperimental diabetes mellitus
dc.subjecthuman
dc.subjectliver
dc.subjectmetabolism
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectoxidative stress
dc.subjectpathology
dc.subjectvascular endothelium
dc.titleMelatonin and L-carnitin improves endothelial disfunction and oxidative stress in Type 2 diabetic rats
dc.typeArticle

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