Cross-sectional analysis of cardiovascular disease and risk factors in patients with spondyloarthritis: a real-life evidence from biostar nationwide registry

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dc.contributor.authorDuruöz M.T.
dc.contributor.authorBodur H.
dc.contributor.authorAtaman Ş.
dc.contributor.authorGürer G.
dc.contributor.authorAkgül Ö.
dc.contributor.authorÇay H.F.
dc.contributor.authorÇapkın E.
dc.contributor.authorSezer I.
dc.contributor.authorRezvani A.
dc.contributor.authorMelikoğlu M.A.
dc.contributor.authorYağcı I.
dc.contributor.authorYurdakul F.G.
dc.contributor.authorGöğüş F.N.
dc.contributor.authorKamanlı A.
dc.contributor.authorÇevik R.
dc.contributor.authorAltan L.
dc.date.accessioned2024-07-22T08:01:21Z
dc.date.available2024-07-22T08:01:21Z
dc.date.issued2024
dc.description.abstractThe association between spondyloarthritis and cardiovascular (CV) diseases is complex with variable outcomes. This study aimed to assess the prevalence rates of CV diseases and to analyze the impact of CV risk factors on CV disease in patients with spondyloarthritis. A multi-center cross-sectional study using the BioSTAR (Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drugs Registry) database was performed on patients with spondyloarthritis. Socio-demographic, laboratory, and clinical data were collected. Patients with and without major adverse cardiovascular events (MACE) were grouped as Group 1 and Group 2. The primary outcome was the overall group’s prevalence rates of CV disease and CV risk factors. The secondary outcome was the difference in socio-demographic and clinical characteristics between the groups and predictive risk factors for CV disease. There were 1457 patients with a mean age of 45.7 ± 10.9 years. The prevalence rate for CV disease was 3% (n = 44). The distribution of these diseases was coronary artery disease (n = 42), congestive heart failure (n = 4), peripheral vascular disorders (n = 6), and cerebrovascular events (n = 4). Patients in Group 1 were significantly male (p = 0.014) and older than those in Group 2 (p < 0.001). There were significantly more patients with hypertension, diabetes mellitus, chronic renal failure, dyslipidemia, and malignancy in Group 1 than in Group 2 (p < 0.05). Smoking (36.7%), obesity (24.4%), and hypertension (13.8%) were the most prevalent traditional CV risk factors. Hypertension (HR = 3.147, 95% CI 1.461–6.778, p = 0.003), dyslipidemia (HR = 3.476, 95% CI 1.631–7.406, p = 0.001), and cancer history (HR = 5.852, 95% CI 1.189–28.810, p = 0.030) were the independent predictors for CV disease. A multi-center cross-sectional study using the BioSTAR (Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drugs Registry) database was performed on patients with spondyloarthritis. Socio-demographic, laboratory, and clinical data were collected. Patients with and without major adverse cardiovascular events (MACE) were grouped as Group 1 and Group 2. The primary outcome was the overall group’s prevalence rates of CV disease and CV risk factors. The secondary outcome was the difference in socio-demographic and clinical characteristics between the groups and predictive risk factors for CV disease. There were 1457 patients with a mean age of 45.7 ± 10.9 years. The prevalence rate for CV disease was 3% (n = 44). The distribution of these diseases was coronary artery disease (n = 42), congestive heart failure (n = 4), peripheral vascular disorders (n = 6), and cerebrovascular events (n = 4). Patients in Group 1 were significantly male (p = 0.014) and older than those in Group 2 (p < 0.001). There were significantly more patients with hypertension, diabetes mellitus, chronic renal failure, dyslipidemia, and malignancy in Group 1 than in Group 2 (p < 0.05). Smoking (36.7%), obesity (24.4%), and hypertension (13.8%) were the most prevalent traditional CV risk factors. Hypertension (HR = 3.147, 95% CI 1.461–6.778, p = 0.003), dyslipidemia (HR = 3.476, 95% CI 1.631–7.406, p = 0.001), and cancer history (HR = 5.852, 95% CI 1.189–28.810, p = 0.030) were the independent predictors for CV disease. The prevalence rate of CV disease was 3.0% in patients with spondyloarthritis. Hypertension, dyslipidemia, and cancer history were the independent CV risk factors for CV disease in patients with spondyloarthritis. © The Author(s) 2024.
dc.identifier.DOI-ID10.1007/s00296-023-05523-y
dc.identifier.issn01728172
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11404
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectAdult
dc.subjectAntirheumatic Agents
dc.subjectCardiovascular Diseases
dc.subjectCoronary Artery Disease
dc.subjectCross-Sectional Studies
dc.subjectDiabetes Mellitus
dc.subjectDyslipidemias
dc.subjectHeart Failure
dc.subjectHumans
dc.subjectHypertension
dc.subjectKidney Failure, Chronic
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasms
dc.subjectObesity
dc.subjectRegistries
dc.subjectRisk Factors
dc.subjectSpondylarthritis
dc.subjectC reactive protein
dc.subjectcholesterol
dc.subjecthigh density lipoprotein
dc.subjectlow density lipoprotein
dc.subjecttriacylglycerol
dc.subjectantirheumatic agent
dc.subjectadult
dc.subjectArticle
dc.subjectcardiovascular disease
dc.subjectcardiovascular risk factor
dc.subjectcerebrovascular accident
dc.subjectchronic kidney failure
dc.subjectchronic obstructive lung disease
dc.subjectcomorbidity
dc.subjectcongestive heart failure
dc.subjectcontrolled study
dc.subjectcoronary artery disease
dc.subjectcross-sectional study
dc.subjectdiabetes mellitus
dc.subjectdyslipidemia
dc.subjectfemale
dc.subjectglomerulus filtration rate
dc.subjectheart infarction
dc.subjecthuman
dc.subjecthypertension
dc.subjectischemic heart disease
dc.subjectischemic stroke
dc.subjectlaboratory test
dc.subjectlipid blood level
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmalignant neoplasm
dc.subjectmedical record review
dc.subjectmulticenter study
dc.subjectobesity
dc.subjectperipheral vascular disease
dc.subjectprevalence
dc.subjectpsoriatic arthritis
dc.subjectrisk factor
dc.subjectsmoking
dc.subjectspondylarthritis
dc.subjecttransient ischemic attack
dc.subjectTurkey (republic)
dc.subjectvalvular heart disease
dc.subjectcardiovascular disease
dc.subjectchronic kidney failure
dc.subjectcomplication
dc.subjectcoronary artery disease
dc.subjectdiabetes mellitus
dc.subjectdyslipidemia
dc.subjectheart failure
dc.subjecthypertension
dc.subjectmiddle aged
dc.subjectneoplasm
dc.subjectregister
dc.subjectspondylarthritis
dc.titleCross-sectional analysis of cardiovascular disease and risk factors in patients with spondyloarthritis: a real-life evidence from biostar nationwide registry
dc.typeArticle

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