The relationship between serum trace element changes and visual function in heavy smokers

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dc.contributor.authorUz E.
dc.contributor.authorSahin S.
dc.contributor.authorHepsen I.F.
dc.contributor.authorVar A.
dc.contributor.authorSogut S.
dc.contributor.authorAkyol Ö.
dc.date.accessioned2024-07-22T08:24:58Z
dc.date.available2024-07-22T08:24:58Z
dc.date.issued2003
dc.description.abstractPurpose: The aim of this prospective study was to evaluate serum manganese (Mn), zinc (Zn) and copper (Cu) levels and visual functions including visual acuity, colour vision, pattern visual evoked potentials (PVEPs), and contrast sensitivity in heavy smokers and to compare these with the equivalent levels and functions in non-smokers. Methods: Data were recorded in 24 healthy, chronic and heavy cigarette smokers and 16 healthy, non-smoking control subjects. Serum Zn, Cu and Mn concentrations in all subjects were measured by atomic absorption spectrophotometry. Results: Both study and control subjects had normal visual acuity and colour vision. Pattern visual evoked potentials were normal in all study and control subjects. Contrast sensitivity was significantly reduced in heavy smokers compared to non-smokers (p < 0.023), despite the fact that central vision and PVEP responses were not affected. Mean serum Mn and Zn levels were significantly lower in smokers than in non-smokers (p < 0.0001 and p < 0.005, respectively). Conclusions: Reduced contrast sensitivity values associated with low levels of serum Mn and Zn, which function as cofactors of superoxide dismutase in erythrocyte and other nucleated cells, suggest a possible role of trace elements in smoking-induced early retinal toxicity.
dc.identifier.DOI-ID10.1034/j.1600-0420.2003.00032.x
dc.identifier.issn13953907
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20206
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectContrast Sensitivity
dc.subjectCopper
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectManganese
dc.subjectMiddle Aged
dc.subjectProspective Studies
dc.subjectSmoking
dc.subjectZinc
dc.subjectcopper
dc.subjectmanganese
dc.subjectsuperoxide dismutase
dc.subjecttrace element
dc.subjectzinc
dc.subjectadult
dc.subjectarticle
dc.subjectatomic absorption spectrometry
dc.subjectblood level
dc.subjectcigarette smoking
dc.subjectcolor vision
dc.subjectcontrast sensitivity
dc.subjectcontrolled study
dc.subjectcopper blood level
dc.subjecterythrocyte
dc.subjectevoked visual response
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman experiment
dc.subjectmale
dc.subjectmedical documentation
dc.subjectnormal human
dc.subjectpriority journal
dc.subjectretina disease
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectstatistical analysis
dc.subjectvisual acuity
dc.subjectvisual impairment
dc.subjectzinc blood level
dc.titleThe relationship between serum trace element changes and visual function in heavy smokers
dc.typeArticle

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