Preparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation

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dc.contributor.authorAvcibasi, U
dc.contributor.authorTürkyarar, T
dc.contributor.authorKaradag, A
dc.contributor.authorBakan, B
dc.contributor.authorYavasoglu, NÜK
dc.contributor.authorKusat, K
dc.contributor.authorAkgöl, S
dc.contributor.authorGülcemal, D
dc.contributor.authorTekin, V
dc.contributor.authorMüftüler, FZB
dc.contributor.authorTopal, G
dc.contributor.authorParlak, Y
dc.contributor.authorGümüser, FG
dc.date.accessioned2025-04-10T10:36:42Z
dc.date.available2025-04-10T10:36:42Z
dc.description.abstractThe aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.
dc.identifier.e-issn1588-2780
dc.identifier.issn0236-5731
dc.identifier.urihttp://hdl.handle.net/20.500.14701/42522
dc.language.isoEnglish
dc.titlePreparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation
dc.typeArticle

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