Association of angiotensin-converting enzyme I/D and eNOS G894T gene polymorphisms with erectile dysfunction; [Converting enzim I/D ve eNOS G894T gen polimorfızmlerinin erektil disfonksiyon ile ilişkisi]

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dc.contributor.authorÇam F.S.
dc.contributor.authorGümüş B.H.
dc.contributor.authorVar A.
dc.contributor.authorBerdeli A.
dc.date.accessioned2024-07-22T08:20:34Z
dc.date.available2024-07-22T08:20:34Z
dc.date.issued2011
dc.description.abstractObjective: Recent studies suggest that angiotensin II and nitric oxide (NO) may modulate penile smooth muscle tone and contractility. Because genotypes of the angiotensin converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) polymorphisms have been associated with disorders in the vascular system, in this study, we investigated an association between the ACE I/D and eNOS G894T gene polymorphisms and erectile dysfunction (ED). Material and Methods: A total of 44 patients and 45 control subjects were included in the study. Diagnosis of erectile dysfunction (< 26) was provided by International Index of Erectile Function (IIEF). The ACE I/D ve eNOS G894T gene polymorphisms were genotyped using PCR and RFLP. Results: No significant case-control difference was observed for the ACE I/D and eNOS G894T gene polymorphisms either by genotype or allele frequencies [(ACE I/D-X2= 0.930 p= 0.628) and eNOS 894 G/T-X2= 2.114 p = 0.348)]. In addition, there was no significant difference between ACE I/D (X2= 3.174 p= 0.787) and eNOS G894T (X2= 4.320 p= 0.633) and IIEF scores among the patient group. Conclusion: In this study, no association was found between ACE I/D and eNOS G894T gene polymorphisms and erectile dysfunction in the Turkish population studied. © 2011 by Türkiye Klinikleri.
dc.identifier.DOI-ID10.5336/medsci.2009-16635
dc.identifier.issn13000292
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18225
dc.language.isoEnglish
dc.publisherTurkiye Klinikleri
dc.rightsAll Open Access; Green Open Access; Hybrid Gold Open Access
dc.subjectangiotensin converting enzyme 2
dc.subjectendothelial nitric oxide synthase
dc.subjectACE gene
dc.subjectadult
dc.subjectaged
dc.subjectallele
dc.subjectarticle
dc.subjectcase control study
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjecterectile dysfunction
dc.subjectethnic group
dc.subjectgene
dc.subjectgene frequency
dc.subjectgenetic association
dc.subjectgenetic polymorphism
dc.subjectgenotype
dc.subjecthuman
dc.subjectInternational Index of Erectile Function
dc.subjectmale
dc.subjectobservational study
dc.subjectpathogenesis
dc.subjectpolymerase chain reaction
dc.subjectrestriction fragment length polymorphism
dc.subjectTurkish
dc.titleAssociation of angiotensin-converting enzyme I/D and eNOS G894T gene polymorphisms with erectile dysfunction; [Converting enzim I/D ve eNOS G894T gen polimorfızmlerinin erektil disfonksiyon ile ilişkisi]
dc.typeArticle

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