Effects of neuronal and glial restricted precursor cells transplantation on erectile function after experimentally induced spinal cord injury

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dc.contributor.authorTemeltas G.
dc.contributor.authorDagci T.
dc.contributor.authorEvren V.
dc.contributor.authorLekili M.
dc.date.accessioned2024-07-22T08:21:53Z
dc.date.available2024-07-22T08:21:53Z
dc.date.issued2009
dc.description.abstractIntroduction.: Erectile dysfunction is common among patients with spinal cord injury (SCI). Aim.: This study aims to investigate the recovery of penile erectile functions of the rats with spinal cord injury (SCI) following transplantation of endogenous neuronal precursors cell (neuronal restricted precursors [NRP]/glial restricted precursors [GRP]) into the injured area of spinal cord. Methods.: Twenty-two rats were experimented in three groups. Group 1 (N = 6): Sham; Group 2 (N = 10): SCI + NRP/GRP transplanted in day 9 after operation; Group 3 (N = 6): SCI + culture medium transplanted in day 9 after operation.Analysis of penile reflexes and cavernosal nerve stimulation studies were performed in day 28 after transplantation for each group. All rats in three groups were then sacrificed and the injured regions of spinal cords underwent histological investigation. Main Outcome Measures.: These results show improvements to some extent in locomotor and erectile functions although these improvements are far from full functional recovery. Results.: Cavernosal nerve stimulation resulted in significantly higher intracavernosal pressure in Group 3 (SCI) although there was no difference between Group 1 (sham) and Group 2 (SCI + NRP/GRP). Number of clusters was similar between groups. Number of erections was higher in Group 3 (SCI) than Groups 1 and 2, and number of cups was higher in Group 2 (SCI + NRP/GRP) than the other two groups. Number of flips was similar in Groups 1 and 2 but lower in Group 3. Number of long flips was highest in Group 1 and lowest in Group 3. The differences between groups were significant. Conclusion.: This study emphasized the healing potential of NRP/GRP transplantation following experimental SCI. However, further experimental and clinical studies are required to advance this treatment modality. © 2009 International Society for Sexual Medicine.
dc.identifier.DOI-ID10.1111/j.1743-6109.2009.01376.x
dc.identifier.issn17436095
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18823
dc.language.isoEnglish
dc.publisherBlackwell Publishing Ltd
dc.subjectAnimals
dc.subjectCell Transplantation
dc.subjectDisease Models, Animal
dc.subjectErectile Dysfunction
dc.subjectLocomotion
dc.subjectMale
dc.subjectNeuroglia
dc.subjectRats
dc.subjectRecovery of Function
dc.subjectSeverity of Illness Index
dc.subjectSpinal Cord Injuries
dc.subjectTreatment Outcome
dc.subjectcyclosporin A
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectcorpus cavernosum
dc.subjectembryo
dc.subjecterectile dysfunction
dc.subjectgraft rejection
dc.subjectlocomotion
dc.subjectmale
dc.subjectnerve stimulation
dc.subjectneural stem cell transplantation
dc.subjectnonhuman
dc.subjectpenis erection
dc.subjectpriority journal
dc.subjectrat
dc.subjectspinal cord injury
dc.subjecttherapy effect
dc.subjectanimal
dc.subjectcell transplantation
dc.subjectconvalescence
dc.subjectcytology
dc.subjectdisease model
dc.subjecterectile dysfunction
dc.subjectglia
dc.subjecthospitalization
dc.subjectmethodology
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectspinal cord injury
dc.subjecttransplantation
dc.subjecttreatment outcome
dc.titleEffects of neuronal and glial restricted precursor cells transplantation on erectile function after experimentally induced spinal cord injury
dc.typeArticle

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