Comparison of diagnostic criteria for children with familial Mediterranean fever

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dc.contributor.authorAkyol Onder E.N.
dc.contributor.authorOzcan K.E.
dc.contributor.authorSahin F.I.
dc.contributor.authorGulleroglu K.S.
dc.contributor.authorBaskin E.
dc.date.accessioned2024-07-22T08:04:49Z
dc.date.available2024-07-22T08:04:49Z
dc.date.issued2022
dc.description.abstractFamilial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent attacks of fever and serositis. Diagnosis is made according to clinical findings and supported by genetic analysis. The most commonly used adult diagnostic criteria are the Tel-Hashomer criteria. Pediatric criteria for FMF diagnosis were described in 2009, but their reliability should be supported by additional reports. In this study, we aimed to compare the pediatric criteria and the Tel-Hashomer and 2019 Eurofever/PRINTO classification criteria using our FMF cohort. A total of 113 patients diagnosed with FMF were included. Demographic features and laboratory findings were retrospectively collected from the patients’ files. The patients were evaluated with the Tel-Hashomer, pediatric and Eurofever/PRINTO classification criteria. At least two of five new pediatric criteria were as sensitive (89%) and specific (85%) as the Tel-Hashomer criteria (sensitivity 70%, specificity 96%). We also evaluated the Eurofever/PRINTO classification criteria using our cohort and found a sensitivity of 94% and specificity of 91%. Conclusion: Using pediatric criteria for the diagnosis of FMF in children is a feasible and simple approach that can diagnose the disease based on at least two criteria. Therefore, our study supports the use of pediatric criteria in FMF diagnosis of children. Our results also confirm that the Eurofever/PRINTO classification criteria can be successfully applied for the diagnosis of FMF due to their high sensitivity (94%) and specificity (91%).What is Known:• The FMF diagnosis is made according clinical findings and supported by genetic analysis.• The use of adult diagnostic criteria in pediatric FMF patients is controversial since classical clinical presentation is often absent in children.What is New:• Our study supports both the use of pediatric criteria and Eurofever/PRINTO classification criteria in clinical practice. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s00431-021-04370-y
dc.identifier.issn03406199
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12863
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.rightsAll Open Access; Green Open Access
dc.subjectChild
dc.subjectCohort Studies
dc.subjectFamilial Mediterranean Fever
dc.subjectFever
dc.subjectHumans
dc.subjectReproducibility of Results
dc.subjectRetrospective Studies
dc.subjectcolchicine
dc.subjectArticle
dc.subjectchild
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectdisease classification
dc.subjecteurofever printo criteria
dc.subjectfamilial Mediterranean fever
dc.subjectfemale
dc.subjectheterozygosity
dc.subjecthomozygosity
dc.subjecthuman
dc.subjectintermethod comparison
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpediatric criteria
dc.subjectpredictive value
dc.subjectretrospective study
dc.subjectschool child
dc.subjectsensitivity and specificity
dc.subjecttel hashomer criteria
dc.subjectfamilial Mediterranean fever
dc.subjectfever
dc.subjectgenetics
dc.subjectreproducibility
dc.titleComparison of diagnostic criteria for children with familial Mediterranean fever
dc.typeArticle

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