The role of energy metabolism and mitochondries at sustained heart; [Ön şartlandirilmiş kalpte enerji metabolizmasinin rolü, mitokondrilerin olasi katkisi]
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Date
2001
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Abstract
A brief period of ischemia and reperfusion has been shown to protect the myocardium against subsequent sustained ischemia and reperfusion injury, which is called "preconditioning". A great number of investigators have explored the mechanism underlying this preconditioning-induced cardioprotection. Several possible mechanisms of energy metabolite contribution to preconditioning effects have bene proposed, including reduction of asidosis, maintenance or facilitation of glycolytic flux rate, contribution of adenosine and preservation of high-energy phosphates. Recent studies have progressivelly explored the role of mitochondrial function in preconditioning cardioprotection. Several factors relating to cardiac mitochondria have been focused on, including energy-producing ability in mitochondria, mitochondrial ATPase, mitochondrial ATP-sensitive K+ channels and contributino of oxygen free radicals generated in mitochondria.