Autoinflammatory conditions: When to suspect? How to treat?

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dc.contributor.authorGrateau G.
dc.contributor.authorDuruöz M.T.
dc.date.accessioned2024-07-22T08:20:44Z
dc.date.available2024-07-22T08:20:44Z
dc.date.issued2010
dc.description.abstractThe term 'autoinflammatory disease' encompasses an enlarging group of inflammatory disorders defined as Mendelian genetic diseases of the innate immune system. This group is growing considering the fact that diseases sharing strong similarities with this core group can be defined as autoinflammatory. The core group consists now of six disorders also known as hereditary recurrent fever syndromes. Thez most common is familial Mediterranean fever, an autosomal recessive disease affecting mainly populations of Mediterranean ancestry. All these six diseases are characterised by inflammatory attacks both at the clinical and at the biological level. The diagnosis of each of these diseases relies first on clinical features and second on genetic testing, which is guided by the clinical results. Deciphering the role of interleukin-1 in the regulation of the inflammatory response through the inflammasome represents a major advance in the knowledge of the mechanisms of these diseases with, as a main consequence, treatment with interleukin-1 inhibitors. © 2009 Elsevier Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.berh.2009.12.009
dc.identifier.issn15216942
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18288
dc.language.isoEnglish
dc.subjectAmyloidosis
dc.subjectAutoimmune Diseases
dc.subjectColchicine
dc.subjectFamilial Mediterranean Fever
dc.subjectGenetic Predisposition to Disease
dc.subjectHereditary Autoinflammatory Diseases
dc.subjectHumans
dc.subjectInflammation
dc.subjectInterleukin-1
dc.subjectSyndrome
dc.subjectcanakinumab
dc.subjectcolchicine
dc.subjectcytokine receptor antagonist
dc.subjectetanercept
dc.subjectinfliximab
dc.subjectmethylprednisolone
dc.subjectrecombinant interleukin 1 receptor blocking agent
dc.subjectrilonacept
dc.subjectthalidomide
dc.subjectinterleukin 1
dc.subjectanaphylactoid purpura
dc.subjectautoinflammatory disease
dc.subjectautosomal dominant disorder
dc.subjectautosomal recessive disorder
dc.subjectCINCA syndrome
dc.subjectclinical assessment
dc.subjectclinical feature
dc.subjectclinical trial
dc.subjectcryopyrinopathy
dc.subjectdrug dose increase
dc.subjectfamilial cold autoinflammatory syndrome
dc.subjectfamilial Mediterranean fever
dc.subjectgenetic disorder
dc.subjectgenetics
dc.subjecthuman
dc.subjectinjection site reaction
dc.subjectinnate immunity
dc.subjectlymphadenopathy
dc.subjectmevalonate kinase deficiency
dc.subjectmevalonic aciduria
dc.subjectMuckle Wells syndrome
dc.subjectPAPA syndrome
dc.subjectpneumonia
dc.subjectpolyarteritis nodosa
dc.subjectpopulation
dc.subjectpriority journal
dc.subjectproteinuria
dc.subjectrecurrent fever
dc.subjectregulatory mechanism
dc.subjectreview
dc.subjectsingle drug dose
dc.subjecttumor necrosis factor receptor associated periodic syndrome
dc.subjectamyloidosis
dc.subjectautoimmune disease
dc.subjectdrug antagonism
dc.subjectfamilial Mediterranean fever
dc.subjectgenetic predisposition
dc.subjecthereditary periodic fever
dc.subjectinflammation
dc.subjectmetabolism
dc.subjectsyndrome
dc.titleAutoinflammatory conditions: When to suspect? How to treat?
dc.typeReview

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