The relationship between paraoxanase gene Leu-Met (55) and Gln-Arg (192) polymorphisms and coronary artery disease; [Paraoksonaz geninde Leu-Met (55) ve Gln-Arg (192) polimorfizmleri ile koroner arter hastaliǧi arasindaki ilişki]

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dc.contributor.authorTaşkiran P.
dc.contributor.authorÇam S.F.
dc.contributor.authorŞekuri C.
dc.contributor.authorTüzün N.
dc.contributor.authorAlioǧlu E.
dc.contributor.authorAltintaş N.
dc.contributor.authorBerdeli A.
dc.date.accessioned2024-07-22T08:21:29Z
dc.date.available2024-07-22T08:21:29Z
dc.date.issued2009
dc.description.abstractObjectives: Paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated esterase that hydrolyses lipoperoxides. PON1 serves as a protective factor against oxidative modification of LDL, suggesting that it may play an important role in the prevention of atherosclerotic process. Research has focused on two polymorphisms: leucine (L allele) to methionine (M allele) substitution at codon 55, and glutamine (A allele) to arginine (B allele) substitution at codon 192. Study design: We examined amino acid changes at codon 55 and 192 in the PON1 gene by polymerase chain reaction and using restriction enzymes in 120 patients (92 men, 28 women; mean age 48.2±4.3 years) with premature coronary artery disease (CAD) and in 102 healthy subjects (80 men, 22 women; mean age 46.8±5.2 years) with no history of CAD and a normal electrocardiogram. Results: Distribution of genotypes in the patient and control groups at codon 55 were 6.7% and 4.9% for MM, 46.7% and 29.4% for LM, 46.7% and 65.7% for LL, respectively. The frequency of genotypes at codon 192 were as follows: 4.2% and 2% for RR, 40% and 35.3% for QR, and 55.8% and 62.8% for QQ, respectively. While the frequency of PON1 55M allele was higher in the CAD group (0.3 vs. 0.2), PON1 192R allele frequency did not differ (0.2). There was a significant relationship between the PON1 M/L55 polymorphism and CAD (p=0.017), whereas the R/Q192 polymorphism was not associated with CAD (p=0.445). Conclusion: These data suggest that the PON1 M/L55 polymorphism shows a significant relationship with CAD and the Q/R192 polymorphism is not a major risk factor causing susceptibility to CAD in our population.
dc.identifier.issn10165169
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18644
dc.language.isoTurkish
dc.subjectAdult
dc.subjectAmino Acid Substitution
dc.subjectArginine
dc.subjectAryldialkylphosphatase
dc.subjectCodon
dc.subjectCoronary Disease
dc.subjectDNA Primers
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenotype
dc.subjectGlutamine
dc.subjectHumans
dc.subjectLeucine
dc.subjectMale
dc.subjectMethionine
dc.subjectMiddle Aged
dc.subjectPolymorphism, Genetic
dc.subjectarginine
dc.subjectaryldialkylphosphatase
dc.subjectesterase
dc.subjectglutamine
dc.subjecthigh density lipoprotein
dc.subjectleucine
dc.subjectlipid peroxide
dc.subjectlow density lipoprotein
dc.subjectmethionine
dc.subjectadult
dc.subjectarticle
dc.subjectcodon
dc.subjectcontrolled study
dc.subjectcoronary artery disease
dc.subjectDNA polymorphism
dc.subjectelectrocardiogram
dc.subjectfemale
dc.subjectgene
dc.subjectgene frequency
dc.subjectgenotype
dc.subjecthuman
dc.subjecthydrolysis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectrisk factor
dc.subjectstatistical significance
dc.titleThe relationship between paraoxanase gene Leu-Met (55) and Gln-Arg (192) polymorphisms and coronary artery disease; [Paraoksonaz geninde Leu-Met (55) ve Gln-Arg (192) polimorfizmleri ile koroner arter hastaliǧi arasindaki ilişki]
dc.typeArticle

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