Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study

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dc.contributor.authorSousa-Pinto, B
dc.contributor.authorLouis, R
dc.contributor.authorAnto, JM
dc.contributor.authorAmaral, R
dc.contributor.authorSá-Sousa, A
dc.contributor.authorCzarlewski, W
dc.contributor.authorBrussino, L
dc.contributor.authorCanonica, GW
dc.contributor.authorLoureiro, CC
dc.contributor.authorCruz, AA
dc.contributor.authorGemicioglu, B
dc.contributor.authorHaahtela, T
dc.contributor.authorKupczyk, M
dc.contributor.authorKvedariene, V
dc.contributor.authorLarenas-Linnemann, DE
dc.contributor.authorOkamoto, Y
dc.contributor.authorOllert, M
dc.contributor.authorPfaar, O
dc.contributor.authorPham-Thi, N
dc.contributor.authorPuggioni, F
dc.contributor.authorRegateiro, FS
dc.contributor.authorRomantowski, J
dc.contributor.authorSastre, J
dc.contributor.authorScichilone, N
dc.contributor.authorTaborda-Barata, L
dc.contributor.authorVentura, MT
dc.contributor.authorAgache, I
dc.contributor.authorBedbrook, A
dc.contributor.authorBecker, S
dc.contributor.authorBergmann, KC
dc.contributor.authorBosnic-Anticevich, S
dc.contributor.authorBonini, M
dc.contributor.authorBoulet, LP
dc.contributor.authorBrusselle, G
dc.contributor.authorBuhl, R
dc.contributor.authorCecchi, L
dc.contributor.authorCharpin, D
dc.contributor.authorde Blay, F
dc.contributor.authorDel Giacco, S
dc.contributor.authorIvancevich, JC
dc.contributor.authorJutel, M
dc.contributor.authorKlimek, L
dc.contributor.authorKraxner, H
dc.contributor.authorKuna, P
dc.contributor.authorLaune, D
dc.contributor.authorMakela, M
dc.contributor.authorMorais-Almeida, M
dc.contributor.authorNadif, R
dc.contributor.authorNiedoszytko, M
dc.contributor.authorPapadopoulos, NG
dc.contributor.authorPapi, A
dc.contributor.authorPatella, V
dc.contributor.authorPétré, B
dc.contributor.authorYeverino, DR
dc.contributor.authorCordeiro, CR
dc.contributor.authorRoche, N
dc.contributor.authorRouadi, PW
dc.contributor.authorSamolinski, B
dc.contributor.authorSavouré, M
dc.contributor.authorShamji, MH
dc.contributor.authorSheikh, A
dc.contributor.authorUlrik, CS
dc.contributor.authorUsmani, OS
dc.contributor.authorValiulis, A
dc.contributor.authorYorgancioglu, A
dc.contributor.authorZuberbier, T
dc.contributor.authorFonseca, JA
dc.contributor.authorCosta, EM
dc.contributor.authorBousquet, J
dc.date.accessioned2025-04-10T10:38:47Z
dc.date.available2025-04-10T10:38:47Z
dc.description.abstractIntroduction Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting beta 2-agonists (ICS+LABA) in users of the MASK-air((R)) app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA. Materials and methods We analysed complete weeks of MASK-air((R)) data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day. Results In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication =80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001). Conclusions In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.
dc.identifier.issn2531-0437
dc.identifier.urihttp://hdl.handle.net/20.500.14701/43368
dc.language.isoEnglish
dc.titleAdherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study
dc.typeArticle

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