Is there a relationship between parathyroid hormone and neutrophil lymphocyte ratio or platelet lymphocyte ratio?

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dc.contributor.authorToraman A.
dc.contributor.authorAras F.
dc.contributor.authorHekimsoy Z.
dc.contributor.authorKursat S.
dc.date.accessioned2024-07-22T08:09:12Z
dc.date.available2024-07-22T08:09:12Z
dc.date.issued2019
dc.description.abstractContext. Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are recent prognostic markers associated with inflammation in many diseases such as chronic kidney disease (CKD), malignancies, myocardial infarction. Objective. In this study, we investigated the relationship between NLR-PLR and parathyroid hormone (PTH) and vitamin D in patients with high PTH levels. Design. The patients with high PTH levels in Nephrology and Endocrinolgy Outpatient clinics were evaluated retrospectively. Subjects and methods. The medical records of the patients were examined and clinical data, including demographic details, clinical and laboratory findings, treatment and follow-up data were obtained. NLR and PLR were calculated. Serum creatinine, calcium, phosphorus, magnesium, lipid levels, calcium phosphorus product, PTH and vitamin D values were investigated. The relationship between NLR-PLR and laboratory parameters, GFR (MDRD-GFR), PTH and vitamin D were investigated. Results. 48 male and 253 female patients were enrolled in this study. The mean age was 57.57±13.28. NLR correlated negatively with albumin, hemoglobin, vitamin D, calcium and cholesterol and it positively correlated with creatinine and PTH. Multiple regression analysis showed that main determinants of NLR were PTH, albumin, LDLcholesterol, hemoglobin and gender. Conclusions. In this study NLR and PLR correlated negatively with hemoglobin and cholesterol. Positive correlation between NLR and creatinine could be explained by increased degrees of inflammation associated with more pronounced degrees of renal dysfunction. The impact of PTH on NLR was independent of GFR. In multiple regression model this suggests that PTH could be a pro-inflammatory parameter independent of the degree of renal dysfunction. © 2019, Acta Endocrinologica Foundation. All rights reserved.
dc.identifier.DOI-ID10.4183/aeb.2019.96
dc.identifier.issn18410987
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14720
dc.language.isoEnglish
dc.publisherActa Endocrinologica Foundation
dc.rightsAll Open Access; Green Open Access
dc.subjectalbumin
dc.subjectcalcium
dc.subjectcholesterol
dc.subjectcreatinine
dc.subjecthemoglobin
dc.subjectlipid
dc.subjectlow density lipoprotein cholesterol
dc.subjectmagnesium
dc.subjectparathyroid hormone
dc.subjectphosphorus
dc.subjectvitamin D
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectblood cell count
dc.subjectchronic kidney failure
dc.subjectcoronary artery disease
dc.subjectdiabetes mellitus
dc.subjectestimated glomerular filtration rate
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjecthyperlipidemia
dc.subjecthyperparathyroidism
dc.subjecthypertension
dc.subjectinflammation
dc.subjectleukocyte differential count
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectneutrophil lymphocyte ratio
dc.subjectparathyroid adenoma
dc.subjectplatelet lymphocyte ratio
dc.subjectretrospective study
dc.subjectvitamin D deficiency
dc.titleIs there a relationship between parathyroid hormone and neutrophil lymphocyte ratio or platelet lymphocyte ratio?
dc.typeArticle

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