A comparison of bupivacaine, bupivacaine-fentanyl and bupivacaine-ketamine in patient-controlled epidural analgesia; [Hasta Kontrollü Analjezi̇de Epi̇dural Bupi̇vakȧin Bupi̇vakai̇n-Fentani̇l ve Bupi̇vakai̇n-Ketaṁiṅin Etki̇leri̇ni̇n Karşilaştirilmasi]

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dc.contributor.authorTekin S.G.
dc.contributor.authorTopçu I.
dc.contributor.authorKefi A.
dc.contributor.authorEnrinçler T.
dc.date.accessioned2024-07-22T08:23:21Z
dc.date.available2024-07-22T08:23:21Z
dc.date.issued2006
dc.description.abstractBackground: In this study, the analgesic and side effects of bupivacaine with combinations of ketamine and fentanyl using patient-controlled-epidural analgesia (PLEA) methods in the postoperative period of total abdominal hysterectomy (TAH) operations were compared. Method: Sixty ASA I-II patients aged between 18-65 years were included, Following epidural catheterization the patients were operated under general anesthesia, After surgery, patients were randomly allocated to 3 groups in a double-blinded fashion to receive PCEA as Group B: 0.125% bupivacaine, Group BF: 0.125% bupivacaine plus 0.1 mg fentanyl and Group BK.: 0.125% bupivacaine plus 40 mg ketamine solutions (10 mL loading dose, 5 mL bolus dose, 10 min lockout time, 30 mL in a 4 hour limit) in 100 mL salin. Hemodynamic parameters, VAS scores, total analgesic consumption, additional analgesic requirements, sedation scores, satisfaction scores and probable side-effects were evaluated for 24 h. Results: Total analgesic consumption was lower in the fentanyl group (p<0.05), Therefore VAS scores in the fentanyl group were lower than the other groups at the 1 hour and the 24 hour assessments (p<0.05), Postoperative analgesic consumption was lower in the ketamine group compared to the control group, There was no difference in side effects and additional analgesic requirement between the groups. Conclusion: Fentanyl and ketamine may be used safely by PCEA for postoperative analgesia, These adjuncts increase analgesic quality and patient satisfaction without increased side effects.
dc.identifier.issn13000578
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19488
dc.language.isoTurkish
dc.subjectbupivacaine
dc.subjectfentanyl
dc.subjectketamine
dc.subjectsodium chloride
dc.subjectabdominal hysterectomy
dc.subjectadjuvant therapy
dc.subjectadult
dc.subjectaged
dc.subjectanalgesic activity
dc.subjectarticle
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdouble blind procedure
dc.subjectdrug safety
dc.subjectepidural anesthesia
dc.subjectepidural catheter
dc.subjectfemale
dc.subjectgeneral anesthesia
dc.subjecthemodynamics
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectpatient controlled analgesia
dc.subjectpatient satisfaction
dc.subjectpostoperative analgesia
dc.subjectpostoperative pain
dc.subjectpostoperative period
dc.subjectrandomized controlled trial
dc.subjectsedation
dc.subjectstatistical significance
dc.subjectunspecified side effect
dc.subjectvisual analog scale
dc.titleA comparison of bupivacaine, bupivacaine-fentanyl and bupivacaine-ketamine in patient-controlled epidural analgesia; [Hasta Kontrollü Analjezi̇de Epi̇dural Bupi̇vakȧin Bupi̇vakai̇n-Fentani̇l ve Bupi̇vakai̇n-Ketaṁiṅin Etki̇leri̇ni̇n Karşilaştirilmasi]
dc.typeArticle

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