Evaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study)

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dc.contributor.authorYilmaz D.
dc.contributor.authorEkemen Keles Y.
dc.contributor.authorEmiroglu M.
dc.contributor.authorDuramaz B.B.
dc.contributor.authorUgur C.
dc.contributor.authorAldemir Kocabas B.
dc.contributor.authorCelik T.
dc.contributor.authorOzdemir H.
dc.contributor.authorBayturan S.
dc.contributor.authorTurel O.
dc.contributor.authorErdeniz E.H.
dc.contributor.authorCakici O.
dc.contributor.authorCakmak Taskin E.
dc.contributor.authorErbas İ.C.
dc.contributor.authorGenceli M.
dc.contributor.authorSari E.E.
dc.contributor.authorCaymaz C.
dc.contributor.authorKizil M.C.
dc.contributor.authorSutcu M.
dc.contributor.authorDemirbuga A.
dc.contributor.authorAlkan G.
dc.contributor.authorBagcı Z.
dc.contributor.authorTimurtas Dayar G.
dc.contributor.authorOzkan E.A.
dc.contributor.authorTekin Yilmaz A.
dc.contributor.authorAkca M.
dc.contributor.authorYesil E.
dc.contributor.authorKara S.S.
dc.contributor.authorAkturk H.
dc.contributor.authorYasar B.
dc.contributor.authorUmit Z.
dc.contributor.authorUygun H.
dc.contributor.authorErdem N.
dc.contributor.authorBuyukcam A.
dc.contributor.authorKaradag Oncel E.
dc.contributor.authorTuter Oz S.K.
dc.contributor.authorCetin H.S.
dc.contributor.authorAnil A.B.
dc.contributor.authorYilmaz R.
dc.contributor.authorZengin N.
dc.contributor.authorUzuner S.
dc.contributor.authorAlbayrak H.
dc.contributor.authorBorakay O.
dc.contributor.authorTopal S.
dc.contributor.authorArslan G.
dc.contributor.authorYazar A.
dc.contributor.authorOzer A.
dc.contributor.authorKendirli T.
dc.contributor.authorKara E.M.
dc.contributor.authorDemirkol D.
dc.contributor.authorBattal F.
dc.contributor.authorKosker M.
dc.contributor.authorMetin Akcan O.
dc.contributor.authorKihtir H.S.
dc.contributor.authorGul D.
dc.contributor.authorZararci K.
dc.contributor.authorAlakaya M.
dc.contributor.authorKula N.
dc.contributor.authorCelik E.
dc.contributor.authorPetmezci E.
dc.contributor.authorEvren G.
dc.contributor.authorKara Aksay A.
dc.contributor.authorKonca C.
dc.contributor.authorSert A.
dc.contributor.authorArslan D.
dc.contributor.authorBornaun H.
dc.contributor.authorTekeli O.
dc.contributor.authorBal A.
dc.contributor.authorSahin I.O.
dc.contributor.authorDemir S.
dc.contributor.authorSap F.
dc.contributor.authorAkyol M.B.
dc.contributor.authorTanidir I.C.
dc.contributor.authorDonmez Y.N.
dc.contributor.authorUcar T.
dc.contributor.authorCoban S.
dc.contributor.authorArga G.
dc.contributor.authorHancerli Torun S.
dc.contributor.authorKarpuz D.
dc.contributor.authorCelik S.F.
dc.contributor.authorVaran C.
dc.contributor.authorElmali F.
dc.contributor.authorOncel S.
dc.contributor.authorBelet N.
dc.contributor.authorHatipoglu N.
dc.contributor.authorDalgic Karabulut N.
dc.contributor.authorTurgut M.
dc.contributor.authorSomer A.
dc.contributor.authorKuyucu N.
dc.contributor.authorDinleyici E.C.
dc.contributor.authorCiftci E.
dc.contributor.authorKara A.
dc.date.accessioned2024-07-22T08:02:03Z
dc.date.available2024-07-22T08:02:03Z
dc.date.issued2023
dc.description.abstractPurpose: Due to its link with the 2019 coronavirus, the multisystem inflammatory syndrome in children (MISC) has garnered considerable international interest. The aim of this study, in which MISC patients were evaluated multicenter, and the data of the third period of the Turk-MISC study group, to compare the clinical and laboratory characteristics and outcomes of MISC patients who did and did not require admission to an intensive care unit (ICU). Methods: This retrospective multicenter observational study was carried out between June 11, 2021, and January 01, 2022. The demographics, complaints, laboratory results, system involvements, and outcomes of the patients were documented. Results: A total of 601 patients were enrolled; 157 patients (26.1%) required hospitalization in the intensive care unit (ICU). Median age was 8 years (interquartile range (IQR) 4.5–11.3 years. The proportion of Kawasaki disease-like features in the ICU group was significantly higher than in the non-ICU group (56.1% vs. 43.2% p = 0.006). The ICU group had considerably lower counts of both lymphocytes and platelets (lymphocyte count 900 vs. 1280 cells × μL, platelet count 153 vs. 212 cells × 103/ μL, all for p< 0.001). C-reactive protein, procalcitonin, and ferritin levels were significantly higher in the ICU group (CRP 164 vs. 129 mg/L, procalcitonin 9.2 vs. 2.2 μg/L, ferritin 644 vs. 334 μg/L, all for p< 0.001). Being between ages 5–12 and older than 12 increased the likelihood of hospitalization in the ICU by four [95% confidence intervals (CI)1.971–8.627] and six times (95% CI 2.575–14.654), respectively, compared to being between the ages 0–5. A one-unit increase in log d-dimer (µg/L) and log troponin (ng/L) was also demonstrated to increase the need for intensive care by 1.8 (95% CI 1.079–3.233) and 1.4 times (95% CI 1.133–1.789), respectively. Conclusion: By comparing this study to our other studies, we found that the median age of MISC patients has been rising. Patients requiring an ICU stay had considerably higher levels of procalcitonin, CRP, and ferritin but significantly lower levels of lymphocyte and thrombocyte. In particular, high levels of procalcitonin in the serum might serve as a valuable laboratory marker for anticipating the need for intensive care. What is Known: • Lymphopenia and thrombocytopenia were an independent predictor factors in patients with MISC who needed to stay in intensive care unit. • The possibility of the need to stay in the intensive care unit in patients with MISC who had Kawasaki disease-like findings was controversial compared with those who did not. What is New: • A one-unit increase log D dimer and log troponin was demonstrated to require for intensive care unit by 1.8 and 1.4 times, respectively. • Serum procalcitonin levels had the best performance to predict stay in the intensive care unit stay. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s00431-023-05207-6
dc.identifier.issn03406199
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11680
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFerritins
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectIntensive Care Units
dc.subjectMucocutaneous Lymph Node Syndrome
dc.subjectpediatric multisystem inflammatory disease, COVID-19 related
dc.subjectProcalcitonin
dc.subjectRetrospective Studies
dc.subjectTroponin
dc.subjectacetylsalicylic acid
dc.subjectalanine aminotransferase
dc.subjectalbumin
dc.subjectamino terminal pro brain natriuretic peptide
dc.subjectanakinra
dc.subjectanticoagulant agent
dc.subjectaspartate aminotransferase
dc.subjectbrain natriuretic peptide
dc.subjectC reactive protein
dc.subjectcorticosteroid
dc.subjectcreatinine
dc.subjectD dimer
dc.subjectferritin
dc.subjectimmunoglobulin
dc.subjectinotropic agent
dc.subjectprocalcitonin
dc.subjectsodium
dc.subjecttroponin
dc.subjecturea
dc.subjectferritin
dc.subjectprocalcitonin
dc.subjecttroponin
dc.subjectabdominal pain
dc.subjectalanine aminotransferase level
dc.subjectalbumin blood level
dc.subjectarthralgia
dc.subjectArticle
dc.subjectaspartate aminotransferase level
dc.subjectchild
dc.subjectchronic disease
dc.subjectclinical outcome
dc.subjectconjunctivitis
dc.subjectcoronary artery aneurysm
dc.subjectcoronavirus disease 2019
dc.subjectcreatinine blood level
dc.subjectdemographics
dc.subjectdermatitis
dc.subjectdiarrhea
dc.subjectdisease duration
dc.subjectechocardiography
dc.subjectfatigue
dc.subjectfemale
dc.subjectfever
dc.subjectfollow up
dc.subjectgastrointestinal symptom
dc.subjectheadache
dc.subjectheart arrhythmia
dc.subjecthospitalization
dc.subjecthuman
dc.subjectimmune deficiency
dc.subjectimmunotherapy
dc.subjectintensive care
dc.subjectinternational normalized ratio
dc.subjectlaboratory test
dc.subjectlength of stay
dc.subjectlip fissure
dc.subjectlymphadenopathy
dc.subjectlymphocyte count
dc.subjectlymphocytopenia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmucocutaneous lymph node syndrome
dc.subjectmulticenter study
dc.subjectmyalgia
dc.subjectneutrophil count
dc.subjectobesity
dc.subjectobservational study
dc.subjectpediatric multisystem inflammatory syndrome
dc.subjectplatelet count
dc.subjectrespiratory tract disease
dc.subjectretrospective study
dc.subjectsensitivity and specificity
dc.subjectserology
dc.subjectshock
dc.subjectsinus bradycardia
dc.subjectsodium blood level
dc.subjectthrombocytopenia
dc.subjecttreatment outcome
dc.subjecturea blood level
dc.subjectvomiting
dc.subjectclinical trial
dc.subjectinfant
dc.subjectintensive care unit
dc.subjectmucocutaneous lymph node syndrome
dc.subjectnewborn
dc.subjectpreschool child
dc.titleEvaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study)
dc.typeArticle

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