Investigation of in vitro antileishmanial activity of moxifloxacin, linezolid and caspofungin on Leishmania tropica promastigotes.

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dc.contributor.authorLimoncu M.E.
dc.contributor.authorEraç B.
dc.contributor.authorGürpinar T.
dc.contributor.authorÖzbilgin A.
dc.contributor.authorBalcioǧlu I.C.
dc.contributor.authorHoşgör-Limoncu M.
dc.date.accessioned2024-07-22T08:18:45Z
dc.date.available2024-07-22T08:18:45Z
dc.date.issued2013
dc.description.abstractThis study aimed to evaluate the potential in vitro anti-leishmanial activities of moxifloxacin, linezolid and caspofungin against Leishmania tropica. In vitro effects of all agents were studied by using the microdilution method. For this purpose, serial dilutions of the aforementioned agents were prepared in concentrations between 4096 μg/mL-0.008 μg/mL. Afterwards, promastigotes incubated in suitable medium were counted with the hemocytometer and adjusted as having a last concentration of 2.5 x 10(6) cells/mL in wells containing medium+antibiotic or antifungal. After incubation live promastigotes were counted with the hemocytometer and inhibitor concentrations (IC(50)) were determined by comparing with the control that contained no antibiotics or antifungal. IC(50) values of moxiloxacin, linezolid and caspofungin were found as 194.7 μg/mL, 896 μg/mL and 235.7 μg/mL, respectively. As a result, moxifloxacin was found to be effective in lower concentrations than the other studied agents against L. tropica promastigotes.
dc.identifier.DOI-ID10.5152/tpd.2013.01
dc.identifier.issn13006320
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17417
dc.language.isoEnglish
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAcetamides
dc.subjectAza Compounds
dc.subjectEchinocandins
dc.subjectLeishmania tropica
dc.subjectOxazolidinones
dc.subjectQuinolines
dc.subjectTrypanocidal Agents
dc.subjectacetamide derivative
dc.subjectantitrypanosomal agent
dc.subjectcaspofungin
dc.subjectechinocandin
dc.subjectheterocyclic compound
dc.subjectlinezolid
dc.subjectmoxifloxacin
dc.subjectoxazolidinone derivative
dc.subjectquinoline derivative
dc.subjectarticle
dc.subjectdrug effect
dc.subjectgrowth, development and aging
dc.subjectLeishmania tropica
dc.titleInvestigation of in vitro antileishmanial activity of moxifloxacin, linezolid and caspofungin on Leishmania tropica promastigotes.
dc.typeArticle

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