Evaluation of markers of inflammation, insulin resistance and endothelial dysfunction in children at risk for overweight

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dc.contributor.authorAkinci G.
dc.contributor.authorAkinci B.
dc.contributor.authorCoskun S.
dc.contributor.authorBayindir P.
dc.contributor.authorHekimsoy Z.
dc.contributor.authorÖzmen B.
dc.date.accessioned2024-07-22T08:22:33Z
dc.date.available2024-07-22T08:22:33Z
dc.date.issued2008
dc.description.abstractOBJECTIVE: Childhood obesity is associated with impaired endothelial function, insulin resistance and inflammation. Being at risk for overweight has been defined as having a body mass index (BMI) between the 85th and 94th percentile for age and sex. In this study, we looked for features linked to cardiovascular risk in children who are at risk for overweight. DESIGN: Twenty-one children who were at risk for overweight (study group) and 20 children with a BMI between the 25th-74th percentiles (controls) were studied. Fasting blood levels of glucose, insulin, total cholesterol, HDL cholesterol, triglycerides, uric acid, fibrinogen and high sensitive C-reactive protein (CRP) were assessed in both groups. LDL-cholesterol, HOMA-IR and QUICKI indices were calculated. Flow-Mediated Vasodilatation (FMD) was determined for the evaluation of endothelial function. RESULTS: Increased HOMA-IR was observed in children who were at risk for overweight. Waist circumference was the main predictor of insulin resistance in these children. Higher levels of CRP were found in the study group compared to controls, while plasma fibrinogen did not differ in the two groups. The children who were at risk for overweight had lower FMD values and slightly elevated lipids compared to controls; however, these differences were not statistically significant. CONCLUSION: Insulin resistance and inflammation indices were higher in children who were at risk for overweight as has been shown for obese children. The data suggest that appropriate treatment strategies for weight control are essential not only for obese children but also for those at risk for overweight.
dc.identifier.DOI-ID10.1007/bf03401507
dc.identifier.issn11093099
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19136
dc.language.isoEnglish
dc.publisherHellenic Endocrine Society
dc.subjectAdolescent
dc.subjectAtherosclerosis
dc.subjectBiological Markers
dc.subjectBlood Glucose
dc.subjectBody Mass Index
dc.subjectC-Reactive Protein
dc.subjectChild
dc.subjectCholesterol, HDL
dc.subjectEndothelium, Vascular
dc.subjectFemale
dc.subjectFibrinogen
dc.subjectHumans
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectMale
dc.subjectObesity
dc.subjectOverweight
dc.subjectRisk Factors
dc.subjectTriglycerides
dc.subjectUric Acid
dc.subjectbiochemical marker
dc.subjectC reactive protein
dc.subjectfibrinogen
dc.subjecthigh density lipoprotein
dc.subjectlow density lipoprotein cholesterol
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectfibrinogen
dc.subjecthigh density lipoprotein cholesterol
dc.subjectinsulin
dc.subjecttriacylglycerol
dc.subjecturic acid
dc.subjectadolescent
dc.subjectarticle
dc.subjectchild
dc.subjectcholesterol blood level
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease marker
dc.subjectendothelial dysfunction
dc.subjectfemale
dc.subjectfibrinogen blood level
dc.subjectglucose blood level
dc.subjecthigh risk population
dc.subjecthuman
dc.subjectinflammation
dc.subjectinsulin blood level
dc.subjectinsulin resistance
dc.subjectlipoprotein blood level
dc.subjectmale
dc.subjectobesity
dc.subjectpreschool child
dc.subjectrisk factor
dc.subjectschool child
dc.subjecttriacylglycerol blood level
dc.subjecturic acid blood level
dc.subjectvasodilatation
dc.subjectwaist circumference
dc.subjectweight control
dc.subjectatherosclerosis
dc.subjectblood
dc.subjectbody mass
dc.subjectimmunology
dc.subjectmetabolism
dc.subjectobesity
dc.subjectvascular endothelium
dc.titleEvaluation of markers of inflammation, insulin resistance and endothelial dysfunction in children at risk for overweight
dc.typeArticle

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