The value of echocardiography versus cardiac troponin i levels in the early detection of anthracycline cardiotoxicity in childhood acute leukemia: Prospective evaluation of a 7-year-long clinical follow-up

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dc.contributor.authorOztarhan K.
dc.contributor.authorGuler S.
dc.contributor.authorAktas B.
dc.contributor.authorArslan M.
dc.contributor.authorSalcioglu Z.
dc.contributor.authorAydogan G.
dc.date.accessioned2024-07-22T08:20:11Z
dc.date.available2024-07-22T08:20:11Z
dc.date.issued2011
dc.description.abstractThe present study was designed to evaluate the significance of echocardiography versus cardiac troponin I levels in early detection of anthracycline dependent cardiotoxicity in acute lymphoblastic leukemia (ALL) patients. A total of 276 pediatric ALL patients were included in the study prospectively along 3 phases of data collection lasted from 2002 to 2009; including phase I (March 2002 to February 2003; n = 25; 53.3% females), phase II (September 2003 to April 2004; n = 35; 57.1% females), and phase III (January 2005 to June 2009; n = 216; 52.7% females) with respect to cumulative anthracycline doses applied. Anthracycline was administered in accordance with berlin-Franfurt-Munich (BFM)-2000 protocol in doses of 30 to 350 mg/m (in the first phase) and 30 to 240 mg/m (in the following phases). Evaluation of cardiotoxicity was performed via echocardiography and measurement of cardiac troponin I levels. Patients in each phase were homogenous in terms of gender and age. Diastolic dysfunction determined via reduction E/A ratio below the cutoff value was demonstrated to deteriorate earlier than systolic functions and alteration in cardiac enzymes. Being similar between dose groups, cTnI levels were shown to rise in the presence of congestive heart failure. In conclusion, anthracycline cardiotoxicity appears to be detected in an earlier stage by using diastolic parameters compared to systolic parameters and cardiac enzymes. © 2011 Informa Healthcare USA, Inc.
dc.identifier.DOI-ID10.3109/08880018.2011.563772
dc.identifier.issn15210669
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18037
dc.language.isoEnglish
dc.subjectAnthracyclines
dc.subjectAntibiotics, Antineoplastic
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDiastole
dc.subjectEarly Diagnosis
dc.subjectEchocardiography
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHeart
dc.subjectHeart Failure
dc.subjectHumans
dc.subjectInfant
dc.subjectMale
dc.subjectPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectSystole
dc.subjectTroponin I
dc.subjectanthracycline
dc.subjectdaunorubicin
dc.subjectdigitalis
dc.subjectdiuretic agent
dc.subjectdoxorubicin
dc.subjectheart enzyme
dc.subjectinotropic agent
dc.subjecttroponin I
dc.subjectacute lymphoblastic leukemia
dc.subjectarticle
dc.subjectcancer chemotherapy
dc.subjectcardiotoxicity
dc.subjectchild
dc.subjectchildhood leukemia
dc.subjectcongestive heart failure
dc.subjectcontinuous infusion
dc.subjectcontrolled study
dc.subjectdiagnostic accuracy
dc.subjectdiagnostic value
dc.subjectdiastolic dysfunction
dc.subjectDoppler echocardiography
dc.subjectdrug dose comparison
dc.subjectearly diagnosis
dc.subjectechocardiography
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectlongitudinal study
dc.subjectM mode echocardiography
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpredictive value
dc.subjectpreschool child
dc.subjectprospective study
dc.subjectprotein blood level
dc.subjectreceiver operating characteristic
dc.subjectschool child
dc.subjectsensitivity and specificity
dc.subjectsystole
dc.subjecttwo dimensional echocardiography
dc.titleThe value of echocardiography versus cardiac troponin i levels in the early detection of anthracycline cardiotoxicity in childhood acute leukemia: Prospective evaluation of a 7-year-long clinical follow-up
dc.typeArticle

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