Adiponectin levels in gestational diabetes mellitus and in pregnant women without glucose intolerance

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dc.contributor.authorPala H.G.
dc.contributor.authorOzalp Y.
dc.contributor.authorYener A.S.
dc.contributor.authorGerceklioglu G.
dc.contributor.authorUysal S.
dc.contributor.authorOnvural A.
dc.date.accessioned2024-07-22T08:14:08Z
dc.date.available2024-07-22T08:14:08Z
dc.date.issued2015
dc.description.abstractObjectives: The aim of the study was to determine serum adiponectin levels among patients with gestational diabetes mellitus (GDM) and normal pregnant women without glucose intolerance, and to investigate the relationship between these levels and clinical factors at the time of the diagnosis, at delivery and in the post-partum period. Material and Methods: The subjects' serum adiponectin concentration was measured using the enzyme-linked immunosorbent assay (ELISA) method at 24th-28th week of gestation, at delivery (in maternal circulation and the umbilical cord) and 24 h after delivery. The relationship between these groups' measurements and other established clinical-laboratory factors were investigated. Results: Serum adiponectin concentrations were significantly lower (p = 0.02) in GDM patients compared with patients with normal glucose tolerance at 24th-28th week of gestation. During delivery, maternal serum adiponectin concentrations were significantly lower (p = 0.03) in GDM patients compared with patients with normal glucose tolerance. In the post-partum period, serum adiponectin concentrations were significantly higher (p = 0.009) in GDM patients compared with patients with normal glucose tolerance. Umbilical cord adiponectin concentrations were significantly lower (p = 0.005) in GDM patients compared with patients with normal glucose tolerance. Conclusions: Adiponectin concentrations in GDM patients' circulation were regulated by changes in glucose and insulin metabolism. A reduction in serum adiponectin levels seems to play a role in GDM patients' insulin resistance. © Copyright by Wroclaw Medical University.
dc.identifier.DOI-ID10.17219/acem/38141
dc.identifier.issn18995276
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16482
dc.language.isoEnglish
dc.publisherWroclaw University of Medicine
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdiponectin
dc.subjectAdult
dc.subjectBlood Glucose
dc.subjectDiabetes, Gestational
dc.subjectFemale
dc.subjectFetal Blood
dc.subjectGlucose Intolerance
dc.subjectHumans
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectPostpartum Period
dc.subjectPregnancy
dc.subjectadiponectin
dc.subjectglucose
dc.subjectinsulin
dc.subjectadiponectin
dc.subjectglucose blood level
dc.subjectinsulin
dc.subjectArticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdelivery
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectgestation period
dc.subjectglucose intolerance
dc.subjectglucose metabolism
dc.subjecthormone blood level
dc.subjecthuman
dc.subjectinsulin metabolism
dc.subjectinsulin resistance
dc.subjectmaternal serum
dc.subjectpregnancy diabetes mellitus
dc.subjectpuerperium
dc.subjectumbilical cord
dc.subjectadult
dc.subjectblood
dc.subjectfetus blood
dc.subjectglucose blood level
dc.subjectmetabolism
dc.subjectpathophysiology
dc.subjectpregnancy
dc.subjectpregnancy diabetes mellitus
dc.titleAdiponectin levels in gestational diabetes mellitus and in pregnant women without glucose intolerance
dc.typeArticle

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