Evaluation of retinal fiber thickness and visual pathways with optic coherence tomography and pattern visual evoked potential in different clinical stages of obstructive sleep apnea syndrome

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dc.contributor.authorKısabay Ak A.
dc.contributor.authorBatum M.
dc.contributor.authorGöktalay T.
dc.contributor.authorMayali H.
dc.contributor.authorKurt E.
dc.contributor.authorSelçuki D.
dc.contributor.authorYılmaz H.
dc.date.accessioned2024-07-22T08:07:16Z
dc.date.available2024-07-22T08:07:16Z
dc.date.issued2020
dc.description.abstractPurpose: To investigate the possible changes in retinal nerve fiber layer (RNFL) by optic coherence tomography and in the amplitudes and peak times (PTs) in pattern visual evoked potential (pVEP) and to compare them in obstructive sleep apnea syndrome (OSAS). Methods: This prospective study included patients with mild OSAS (n = 30), severe OSAS (n = 30), and 30 control subjects. All patients were assessed after obtaining the approval from our hospital’s ethics committee. Results: There was no difference in age and gender between the groups (p = 0.184, p = 0.954). By analysis of variance, there was a significant difference in RNFL values among patients with mild OSAS, severe OSAS, and control for three measures of RNFL (average p = 0.044, nasal p = 0.003, inferior p = 0.027). In severe OSAS group, nasal and inferior quadrants of the RNFL were found to be thinner than the control group (p = 0.008, p = 0.031). We showed that the PT of P100 and N145 was prolonged in severe OSAS compared to the control group (p < 0.001) and that PT of P100 was prolonged in mild OSAS compared to the control group (p < 0.05). The amplitude of N75-P100 was significantly decreased in patients with both severe OSAS and mild OSAS compared to the control group (p < 0.001). Correlation of RNFL and pVEP values showed that the inferior quadrant RNFL thickness is correlated with both P100 and N145 PTs (r = 0.271*, p = 0.036 and r = 0.290*, p = 0.043, respectively) and N75-P100 amplitude (r = 0.378**, p = 0.003) in severe OSAS group. Conclusions: In mild and severe stages of the disease, edema and inflammation were evident and VEP PT and amplitudes were affected in both groups. Furthermore, thinning in RNFL in the severe stage of the disease might be associated with higher atrophy levels and prolonged exposure to hypoxia. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s10633-020-09749-0
dc.identifier.issn00124486
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13881
dc.language.isoEnglish
dc.publisherSpringer
dc.subjectAdult
dc.subjectAged
dc.subjectElectroretinography
dc.subjectEvoked Potentials, Visual
dc.subjectFemale
dc.subjectHumans
dc.subjectIntraocular Pressure
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNerve Fibers
dc.subjectPolysomnography
dc.subjectProspective Studies
dc.subjectRetinal Ganglion Cells
dc.subjectSleep Apnea, Obstructive
dc.subjectTomography, Optical Coherence
dc.subjectTomography, X-Ray Computed
dc.subjectVisual Pathways
dc.subjectadult
dc.subjectage
dc.subjectArticle
dc.subjectatrophy
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectevaluation study
dc.subjecteye edema
dc.subjecteye examination
dc.subjecteye inflammation
dc.subjectfemale
dc.subjectgender
dc.subjecthuman
dc.subjecthypoxia
dc.subjectmale
dc.subjectmiddle aged
dc.subjectoptical coherence tomography
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectretinal nerve fiber layer thickness
dc.subjectsleep disordered breathing
dc.subjecttime factor
dc.subjectvisual evoked potential
dc.subjectvisual system
dc.subjectaged
dc.subjectelectroretinography
dc.subjectintraocular pressure
dc.subjectnerve fiber
dc.subjectoptical coherence tomography
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectpolysomnography
dc.subjectprocedures
dc.subjectretina ganglion cell
dc.subjectsleep disordered breathing
dc.subjectvisual evoked potential
dc.subjectvisual system
dc.subjectx-ray computed tomography
dc.titleEvaluation of retinal fiber thickness and visual pathways with optic coherence tomography and pattern visual evoked potential in different clinical stages of obstructive sleep apnea syndrome
dc.typeArticle

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