The role of oligoclonal band count and IgG index in treatment response and disease activity in multiple sclerosis

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dc.contributor.authorTaşkıran E.
dc.contributor.authorTerzi M.
dc.contributor.authorHelvacı E.M.
dc.contributor.authorEser M.Z.
dc.contributor.authorAvcı B.
dc.contributor.authorÖmer Faruk T.
dc.contributor.authorYetkin M.F.
dc.contributor.authorÇilingir V.
dc.contributor.authorBir L.S.
dc.contributor.authorKabay S.C.
dc.contributor.authorBilge N.
dc.contributor.authorPoyraz T.
dc.contributor.authorDemir C.F.
dc.contributor.authorDündar D.K.
dc.contributor.authorOcak Ö.
dc.contributor.authorÇam M.
dc.contributor.authorMavioğlu H.
dc.contributor.authorAltun Y.
dc.contributor.authorKaraibrahimoğlu A.
dc.date.accessioned2024-07-22T08:01:34Z
dc.date.available2024-07-22T08:01:34Z
dc.date.issued2024
dc.description.abstractBackground/aim: Multiple sclerosis (MS) is an inflammatory demyelinating central nervous system (CNS) disease. Among the paraclinical tests, brain and spinal Magnetic Resonance Imaging (MRI) is primarily involved in the diagnosis process, and cerebrospinal fluid (CSF) analysis is fundamental in diagnosing MS and the differential diagnosis. A positive relationship was demonstrated between oligoclonal band (OCB) positivity, CSF band number and immunoglobulin G(IgG) index. The study aimed to evaluate whether the number of OCB can predict disease activity and determine a correlation with the IgG index. Methods: Our study included 401 MS patients who had relapsing-remitting multiple sclerosis (RRMS), primary progressive multiple sclerosis (PPMS), secondary progressive multiple sclerosis (SPMS), clinic isolated syndrome (CIS), radiologic isolated syndrome (RIS), Neuromyelitis optica spectrum disorder (NMOSD) and Acute disseminated encephalomyelitis (ADEM) with OCB number groups of 2–4, 4–8, 8–12, and 12 and above. Results: No significant correlation was observed between IgG index, pre-and post-treatment EDSS (Expanded Disability Status Scale Scores) and disease-modifying therapies (DMT). Drug response was better in the patient group with band number between 2 and 8 and post-treatment EDSS scores were lower (1.62±0.44). Conclusion: The study results suggested that band number may be as valuable as the IgG index and a predictive biomarker for disease activity. © 2023
dc.identifier.DOI-ID10.1016/j.msard.2023.105391
dc.identifier.issn22110348
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11488
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectHumans
dc.subjectImmunoglobulin G
dc.subjectMultiple Sclerosis
dc.subjectMultiple Sclerosis, Chronic Progressive
dc.subjectMultiple Sclerosis, Relapsing-Remitting
dc.subjectOligoclonal Bands
dc.subjectazathioprine
dc.subjectdisease modifying antirheumatic drug
dc.subjectfingolimod
dc.subjectimmunoglobulin G
dc.subjectmethotrexate
dc.subjectnatalizumab
dc.subjectocrelizumab
dc.subjectoligoclonal band
dc.subjectteriflunomide
dc.subjectimmunoglobulin G
dc.subjectoligoclonal band
dc.subjectacute disseminated encephalomyelitis
dc.subjectadult
dc.subjectArticle
dc.subjectcentral nervous system disease
dc.subjectcerebrospinal fluid analysis
dc.subjectclinical evaluation
dc.subjectdemyelinating disease
dc.subjectdifferential diagnosis
dc.subjectdisease activity
dc.subjectdisease exacerbation
dc.subjectExpanded Disability Status Scale
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultiple sclerosis
dc.subjectmyelooptic neuropathy
dc.subjectnuclear magnetic resonance imaging
dc.subjectradiologic isolated syndrome
dc.subjecttreatment response
dc.subjectcerebrospinal fluid
dc.subjectdiagnostic imaging
dc.subjectprogressive multiple sclerosis
dc.subjectrelapsing remitting multiple sclerosis
dc.titleThe role of oligoclonal band count and IgG index in treatment response and disease activity in multiple sclerosis
dc.typeArticle

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